I am taking now 40 mg of Sprycel with 30 mg of pioglitazone.
The last PCR test was good. The pleural effusion is less.
Hi Survenant, How long have you been dealing with your pleural effusion and how much of a decrease did you experience with this additional drug?
I was diagnosed 12/13 started Sprycel @ 100mg but had to reduce the dose due to severe side effects to 70 then 50 then 20 finally 20 every other day. My oncologist stopped Sprycel 12-16 and started Gleevec to alleviate the pleural effusion. I only lasted 40 days on Gleevec as I developed a severe full body edema along with the pleural effusion. I had been undetectable since June 2015. I have been dealing with a severe bilateral pleural effusion since 6-2015. The dose reduction did not decrease the amount of the pleural effusion. My oncologist agreed to stop Sprycel for a three month period, testing at 6 weeks and again at the 3 month deadline. Unfortunately,my BCR-ABL came back at .039 at the six week deadline. I'm back on Sprycel 20 mg daily and will have another catheter implanted to cut down on the hospital visits for thorocentesis. I am not a good candidate for Tasigna because I've had a stroke have a stent in one carotid artery and am evaluated on a regular basis to track the other carotid artery. We're wondering if Pioglitazone may help to reduce the pleural effusion.