Posted 27 April 2016 - 07:28 PM
I think it means what you think it means - although, if they don't test it, they must be doing estimations...
This excerpt is from Iriyama (2015) Shorter halving time of BCR-ABL1 transcripts is a novel predictor for achievement of molecular responses in newly diagnosed chronic-phase chronic myeloid leukemia treated with dasatinib: Results of the D-first study of Kanto CML study group. Am J Hematol. 2015 Apr;90(4):282-7. doi: 10.1002/ajh.23923.
The halving time for BCR-ABL1 transcripts was expressed with following formula: Halving time = A × Log10 2/log10 (B/C), where A = the actual treatment time in days, from the day of the initial evaluation of BCR-ABL1 before treatment to the evaluation for BCR-ABL1 transcript at 3 months; B = BCR-ABL1 transcript value before treatment (copies/μg RNA); and C = BCR-ABL1 transcript value at 3 months (copies/μg RNA).
My understanding of the point of these "halving time" papers, is that they are looking for further ways (as well as the 3-month less than 10% one) to predict how well people will do on the medications, presumably, so they can switch or do something to optimise outcomes in people who may not be likely to respond well longer term.
e.g., They already know that if you reach less than 10% at 3 months, you are more likely to reach MMR than someone who doesn't reach 10% at 3m months - so I think they are looking for further ways of discriminating the non-responders.
*I think* (please correct me if I'm wrong, Trey ) this paper above is trying to emphasise the importance of measuring BCR-ABL at baseline so you know how *fast* it is reducing as well as the raw number of the BCR-ABL at 3 months, both of which appear to be important.
Diagnosed 9 June 2011, Glivec 400mg. Commenced monthly testing when MR4.0 lost during 2012.
2017: <0.01, <0.01
2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)
2015: <0.01, <0.01, <0.01, 0.013
2014: PCRU, <0.01, <0.01, <0.01, <0.01
2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01
2012: <0.01, <0.01, 0.013, 0.032, 0.021
2011: 38.00, 12.00, 0.14