Posted 11 February 2016 - 02:16 PM
The fact is, we, the taxpayers, fund the development of drugs to fight cancer:
NIH's FY2016 funding $32 billion ... NIH's funding is awarded through almost 50,000 competitive grants to more than 300,000 researchers at more than 2,500 universities.
Other research funding is from LLS, and various Cancer groups, from the donations they receive.
The rewards go to the heads of the university labs and the pharmaceutical companies who pick up the drugs and see them through to FDA approval.
Had a friend who was assistant blood lab director at one of our most prominent universities. One of her main duties, along with managing the lab on a day-to-day basis, was to write the grant applications to submit to the NIH, and others. She told me of the very large rewards received by the head of the lab when their research enabled BIG PhRMA to capitalize on another new drug. We, the patients, are being gamed in every way imaginable.
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt