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Age Does Not Affect Response to Imatinib in CML


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#1 Buzzm1

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Posted 21 April 2011 - 10:41 AM

Age Does Not Affect Response to Imatinib in CML

http://bit.ly/fcphkr


Data from a new study show for the first time that age does not affect response to imatinib, and overall survival for CML is similar in older and younger patients who receive the treatment.


The authors of the study, published online March 29 in Blood, observed that at 3 months, a complete hematologic response was observed in 97% of older patients (65 years and older) and in 96% of younger patients.


At 6 months, 69% of older patients achieved a complete cytogenetic response, as did 67% of younger patients. This pattern was observed at 12- and 24-month follow-up (78% vs 77% and 74% vs 78%, respectively).


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#2 Buzzm1

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Posted 21 April 2011 - 11:16 AM

http://bit.ly/fRGkAq

The four general stages of treatment are:


beginning at 100 when diagnosed


hematologic response - means that blood cell counts have normalized

cytogenetic response - a reduction to <1 a 2 log reduction

major molecular response - a reduction to <0.1 a 3-log reduction

complete molecular response - a reduction to <0.01 a 4 log reduction

A hematologic response means that blood cell counts have normalized-most patients achieve a hematologic response on Gleevec. A cytogenetic response means there are no Leukemic cells (Ph+ cells) that can be detected by the FISH and cytogenetic tests. PCR is a very sensitive test that looks for Ph+ cells (the trademark of CML) in the blood. When initially diagnosed, the average patient has a 100 (int'l scaled) score on the PCR test. That score usually drops to around a 1.0 when the patient achieves a complete cytogenetic response. And when the PCR score drops to 0.1, the patient is deemed to have achieved a major molecular response. Achieving a major molecular response within the first 18 months of treatment is important, because most of the patients that achieve that benchmark remain "free from progression" to more accelerated forms of the disease five years later. (Gleevec is still a relatively new drug, so we don't have a lot of data beyond 5 years out.) A complete molecular response usually means a score less than 0.01, a level below what the lab is able to detect in the patient's blood-what is called "remission" in cancer terminology. Unfortunately, Gleevec is not a "cure," so patients who are successful on the drug usually remain on the drug indefinitely to stay in remission.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt





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