Hi. I'm new to the group... trying not to feel scared... I've been in treatment for CML since Dec. 2006, and have been doing great. Took Gleevec for 6 years, and then was switched to Sprycel in 2012 (because my new doc insisted on getting the PCR test to "no detection" result). For 11 years, when there is a positive reading on my PCR test, it's always been for the b2a2 transcript (BCR-ABL).
Last month my test read "no detection" for that transcript BUT read positive for the b3a2 transcript. What was most concerning, though, was that my doctor couldn't explain that. His response was, "Yeah, that's kind of confusing." Without going into more detail, I'm wondering:
- Has this happened to anyone else?
- Does anyone know what this might mean?
- What other treatments have members found success with after Gleevec and Sprycel?
Thanks so VERY much for any information anyone has.