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Cost of Generic Imatinib just got higher!


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#61 Buzzm1

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Posted 29 November 2017 - 03:31 PM

Thanks for the update shweflen.  Glad to see the Humana Walmart quoted price on generic imatinib mesylate is somewhat lower than expected, although, as you said, there is no guarantee.  Wanted to mention that it is not unusual to see a bounce in a PCR value after initially reaching undetected; looking forward to seeing you at undetected again with your next test.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#62 shweflen

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Posted 29 November 2017 - 04:06 PM

Thanks for the update shweflen.  Glad to see the Humana Walmart quoted price on generic imatinib mesylate is somewhat lower than expected, although, as you said, there is no guarantee.  Wanted to mention that it is not unusual to see a bounce in a PCR value after initially reaching undetected; looking forward to seeing you at undetected again with your next test.

Thanks for the encouragement.  I know that I shouldn't worry too soon but I am a bit anxious to see the next test results.  I had a sample taken yesterday and will see the hematologist on Tuesday so I don't have to wait much longer.


10/20/2016 BCR-ABL:ABL = 81.622

01/11/2017 BCR-ABL:ABL =   8.028

04/12/2017 BCR-ABL:ABL =   0.157

07/07/2017 BCR-ABL:ABL =   0.000

10/04/2017 BCR-ABL:ABL =   0.041

11/28/2017 BCR-ABL:ABL =   0.000

 

 


#63 ROMO

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Posted 29 November 2017 - 06:23 PM

thatguy,

 

I did go through some of the offerings and noticed words like, Laboratory
use only, and Veterinary Antiseptic, and 97% pure, and Hot Seller, and
Top Quality Food Grade, and even,  Adults and Children.
They could have ment Adult and Children Gerbils.
Some of them did say for CML treatment.
 
They also sold quantities like 25 kilograms a month. And payment plans
like Pay Pal and Western Union. Just call them and they will work it out.
They will even UPS it.
Imagine having 50 pounds of Gleevic in your garage.
 
Reminds me of a story some years ago when all these pet dogs started
dying in the US. The vets in their trade journals started talking and traced
it to a protein substance in pet treats. This was later traced to a mom and
pop lab in China. It made the national news here and the politicians got
involved and the Chinese government was shamed into punishing the
culprit. So they rounded up the owner of the Lab and shot him.
If you shame the Chinese government they shoot you.
In America they give you a talk show.
 
Maybe I could start up a Go-Fund-Me page and try some of this stuff.
A chance to die rich. I could put it on my headstone...
 
 "Here lies Romo, This years Darwin Award Winner!
Buried with his favorite book,  "The Book of Bad Ideas".
...Rest in Peace.
 
Happy Holidays
 
 
Romo 

DX August 2016. WBC ~160K
PH+ Cells 36%
No Spleen enlargement
No Symptoms. Other counts ~Normal
BCR-ABL p210 (Detected)
BCR-ABL p190 (Not Detected)
 
Sprycel 100mg.
PCR   02/01/2017    0.146 IS
PCR   08/07/2017    0.022 IS
Next PCR:           12/XX/2017
 

#64 Buzzm1

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Posted 29 November 2017 - 06:48 PM

I had a sample taken yesterday and will see the hematologist on Tuesday so I don't have to wait much longer.

Hoping Tuesday brings you good news shweflen.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#65 thatguy

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Posted 29 November 2017 - 11:46 PM


thatguy,

I did go through some of the offerings and noticed words like, Laboratory
use only, and Veterinary Antiseptic, and 97% pure, and Hot Seller, and
Top Quality Food Grade, and even, Adults and Children.
They could have ment Adult and Children Gerbils.
Some of them did say for CML treatment.

They also sold quantities like 25 kilograms a month. And payment plans
like Pay Pal and Western Union. Just call them and they will work it out.
They will even UPS it.
Imagine having 50 pounds of Gleevic in your garage.

Reminds me of a story some years ago when all these pet dogs started
dying in the US. The vets in their trade journals started talking and traced
it to a protein substance in pet treats. This was later traced to a mom and
pop lab in China. It made the national news here and the politicians got
involved and the Chinese government was shamed into punishing the
culprit. So they rounded up the owner of the Lab and shot him.
If you shame the Chinese government they shoot you.
In America they give you a talk show.

Maybe I could start up a Go-Fund-Me page and try some of this stuff.
A chance to die rich. I could put it on my headstone...

"Here lies Romo, This years Darwin Award Winner!
Buried with his favorite book, "The Book of Bad Ideas".
...Rest in Peace.

Happy Holidays


Romo


Lol, I'd contribute! Just give us the raw-dog, honest truth!

I mean seriously lets just find an honest chemist and a test lab, and do some bartering...?
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#66 Dom

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Posted 30 November 2017 - 01:24 PM

Buzz: "Hoping to hear from Dom too"

Hi buzz. Yes, I signed up with Cigna part D in 2018. Like sweflen, I'm concerned about the two star ratings, but since I'm not sure what that means, I'm not overly concerned.

According to the Medicare plan finder, my 2018 bill should total $8,500. But according to the Cigna site it should be $11,500. Anyone's guess. I didn't see any better plans. I'd like to move to an advantage plan but the prescription copays are much higher. If the true bill is $11,500 I may move to advantage in 2019.

Diagnosed in February 2014. Started Imatinib 400 in April.
2014:     3.18     0.91
2015:     0.22     0.16     0.04     0.55
2016:     0.71     0.66

(Started Imatinib 600 in April 2016)
2016:     0.42     0.13     0.45
2017:     0.17     0.06     0.10     0.06     0.34


#67 Buzzm1

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Posted 30 November 2017 - 03:14 PM

Thanks for the update Dom.  Good Luck on the 2018 generic imatinib mesylate pricing.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#68 SandyG353

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Posted 04 December 2017 - 03:28 PM

My daughter takes Gleevec and was offered the generic.    It is interesting because in her prescription plan, Novartis lowered the price of Gleevec to match the co-pay of the generic.  So, she only pays $10 for brand.



#69 Buzzm1

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Posted 04 December 2017 - 09:49 PM

Glad to see you are back on track shweflen.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#70 shweflen

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Posted 05 December 2017 - 09:48 AM

Glad to see you are back on track shweflen.

Thank you.  I know how lucky I am and appreciate all the information and support you and the others here provide.


10/20/2016 BCR-ABL:ABL = 81.622

01/11/2017 BCR-ABL:ABL =   8.028

04/12/2017 BCR-ABL:ABL =   0.157

07/07/2017 BCR-ABL:ABL =   0.000

10/04/2017 BCR-ABL:ABL =   0.041

11/28/2017 BCR-ABL:ABL =   0.000

 

 


#71 campanula

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Posted 14 December 2017 - 04:01 PM

Looks like Teva Pharmaceuticals is in trouble.  Strangely enough, I will take my first Teva tablet today (have been taking Sun with one month of Apotex.)  I don't know why I was shipped Teva this time.

 

-----------------------------------------------------

 

"JERUSALEM — Teva Pharmaceutical Industries Ltd., the world's largest generic drugmaker, on Thursday said it would lay off over a quarter of its workforce as part of a global restructuring meant to salvage its ailing business.

 
The company said 14,000 workers would be let go. The cuts will be scattered across Teva's global operations and will occur over the next two years, with most expected in 2018."

 

https://www.msn.com/...ID=ansmsnnews11


Dx 2/16: PCR = 59.4%

BMB showed second translocation.

400 mg generic Imatinib

5/16:  PCR = 0.88%

8/16: PCR = 0.04%

11/16 PCR = 0.01%

2/17 PCR < 0.01%

2/17 BMB results:  all translocations gone.

6/17 PCR = 0.03%

9/17 PCR = 0.01%

1/18 PCR = 0.01%

 

 


#72 campanula

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Posted 16 December 2017 - 12:20 PM

And yesterday, the founder of Apotex was found dead in his mansion in Toronto.

 

https://www.msn.com/...ID=ansmsnnews11


Dx 2/16: PCR = 59.4%

BMB showed second translocation.

400 mg generic Imatinib

5/16:  PCR = 0.88%

8/16: PCR = 0.04%

11/16 PCR = 0.01%

2/17 PCR < 0.01%

2/17 BMB results:  all translocations gone.

6/17 PCR = 0.03%

9/17 PCR = 0.01%

1/18 PCR = 0.01%

 

 


#73 r06ue1

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Posted 19 December 2017 - 10:28 AM

Yeah, that is a bit suspicious.  Also, Teva (another generic manufacturer) is restructuring and laid off 14,000 employees.  

 

https://www.fierceph...ment-of-justice


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#74 snowboots

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Posted 19 December 2017 - 06:55 PM

Well, you were all correct in that the Novartis co-pay card will not work for the Medicare Part D programs. In previous posts I was mistaken about this - my bad. The "good" news is that I have found a prescription drug plan called EnvisionRxPlus. $12.60/mo. premium and a total cost of $7590 for generic imatinib mesylate. A total of $7741 for the year, which is much less than a lot of the plans I researched. Hopefully these prices will hold. Late in the game now for most of you for next year, but maybe worth keeping in mind. Still a mind-blower for me though. My previous insurance (ExpressScripts) had a $5 co-pay for a 90 day supply of brand name Gleevec. Turning 65 is disheartening.(was going to use the "B" word, but didn't know if I'd get canned).



#75 Buzzm1

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Posted 19 December 2017 - 07:16 PM

Well, you were all correct in that the Novartis co-pay card will not work for the Medicare Part D programs. In previous posts I was mistaken about this - my bad. The "good" news is that I have found a prescription drug plan called EnvisionRxPlus. $12.60/mo. premium and a total cost of $7590 for generic imatinib mesylate. A total of $7741 for the year, which is much less than a lot of the plans I researched. Hopefully these prices will hold. Late in the game now for most of you for next year, but maybe worth keeping in mind. Still a mind-blower for me though. My previous insurance (ExpressScripts) had a $5 co-pay for a 90 day supply of brand name Gleevec. Turning 65 is disheartening.(was going to use the "B" word, but didn't know if I'd get canned).

Thanks for the update snowboots.  


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#76 hannibellemo

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Posted 20 December 2017 - 07:42 PM

@snowboots, I'm going to use the "f-word" abbreviation in this.

 

All the talk about "congress" not allowing Medicare to negotiate, yet we, who are on Medicare, are the fastest growing cohort and those f***ers keep getting re-elected! We have met the enemy, is it us?

 

I realize this is a simplification and I wouldn't wish CML on anyone (ok, maybe some members of congress and one or two others in the government) but the high cost of drugs has to be affecting more than just us with CML.

 

Heard on NPR yesterday that there is a treatment for a certain type of blindness, the treatment is expected to cost $1,000,000 dollars! Huh?


Pat

 

"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>


#77 Buzzm1

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Posted 20 December 2017 - 08:21 PM

I wholeheartedly agree with you Pat.  Congress is in the back pocket of Big PhRMA and is allowing Big PhRMA to run roughshod over the American people with the price of drugs .  There isn't any restriction as to how much Big PhRMA can charge for drugs; now, even generic drugs, as we have seen with generic Imatinib mesylate, are escalating in price.

 

Just a day, or two, ago, there was an article about a drug company that recently purchased another drug company which had been essentially giving away a drug that they held a patent on.  The purchasing company then increased the price of that "essentially free" drug to $15,000 per Rx.  Here's the article.

 

and other articles:
https://news.google....en&gl=US&ned=us

 

Insurance companies are effectively in collusion with Big PhRMA as the more Big PhRMA charges, the more insurance companies make.  Pharmacies and Pharmacists aren't complaining either.

 

Because medical insurance covers drugs, the public ire isn't being raised.  When you turn 65 and are on Medicare Part D you quickly become aware of high drug prices as you begin paying large amounts out-of-pocket.

 

There ought to be a law, or at least Congress should be fighting on our behalf rather that accepting money from Big PhRMA and turning their back on us.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#78 r06ue1

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Posted 21 December 2017 - 06:37 AM

The problem is the US is not a Democracy, never was, is supposedly a Republic, but since the 80's has looked more and more like an Oligarchy, Plutocracy, Aristocracy and Kleptocracy all rolled in to one.


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#79 Buzzm1

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Posted 23 December 2017 - 12:14 PM

Going into 2018, based on information provided by Medicare Part D subscribers Shweflen, Snowboots, and Dom, it appears that U.S. generic Imatiinib Mesylate, as produced by Sun, Apotex, and Teva, is being priced at a little less than 50% of the cost of Novartis's Gleevec.

 

For the first seven months of 2017, Apotex had priced their generic imatinib mesylate, available through Express Scripts at Walmart, at about 20% of the brand name Gleevec price.  In August Apotex inexplicably more than tripled their price of generic mesylate., rivaling the prices being charged by Sun and Teva.

 

I'm not aware that any additionall generic Imatinib Mesylate manufacturers have entered the U.S. market for 2018.


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#80 chriskuo

chriskuo

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Posted 23 December 2017 - 01:56 PM

Teva will need to make as much money as possible from imatinib until they get the mess of a company restructured. Hope they don't skimp on quality control.

The disheartening thing is that Americans support politicians who prevent Medicare from negotiating drug prices. And these are the politicians who shout America First.




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