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Newcastle researchers welcome CML leukaemia trial success

Started by gerry , Jan 25 2017 04:51 AM

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7 replies to this topic

#1 gerry

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Posted 25 January 2017 - 04:51 AM

New research could see patients with a rare blood cancer live longer without the side-effects of drugs, doctors say.

Chronic myeloid leukaemia (CML) patients are often required to take tyrosine kinase inhibitors (TKIs) indefinitely.

But 93% of those in a new study stayed cancer-free after stopping or reducing treatment.

Cancer Research UK said the results were "promising" but dosages should not be changed without a doctor's advice.

In 2000, trials of TKIs proved successful in controlling the rare disease, but also had side-effects, including an increased risk of infection, skin rashes, nausea, hair loss and in some cases hormone disorder and a build of fluid around the heart.

The follow-up study, led by the University of Liverpool and involving consultants from Newcastle's Freeman Hospital, saw patients being given half the standard dose for the first 12 months. If leukaemia levels remained low, the drug was then stopped completely.

So far, out of 174 patients tested, 93% have shown no evidence of their leukaemia relapsing one year after reducing their dosage and many reported a significant decrease in side-effects within the first three months. http://www.bbc.com/n...-tyne-38680482

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#2 Trey

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Posted 25 January 2017 - 09:44 AM

Your Aussie links have some issues working.

http://www.bbc.com/n...d-tyne-38680482

Just to be clear, the 93% success rate was for the reduced dosage, not for cessation.

http://www.onclive.c...merging-for-cml

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#3 rcase13

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Posted 25 January 2017 - 10:17 AM

But that is great! This will help sway doctors to reduce dosage.

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg

04/08/2015 0.01% Tasigna 600mg

07/01/2015 0.01% Tasigna 600mg

10/05/2015 0.02% Tasigna 600mg

01/04/2016 0.01% Tasigna 600mg

04/04/2016 PCRU Tasigna 600mg

07/18/2016 PCRU Tasigna 600mg

10/12/2016 PCRU Tasigna 600mg

01/09/2017 PCRU Tasigna 600mg

04/12/2017 PCRU Tasigna 600mg

10/16/2017 PCRU Tasigna 600mg

01/15/2018 PCRU Tasigna 600mg

Cancer Sucks!

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#4 Trey

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Posted 25 January 2017 - 11:24 AM

Exactly. First data I have seen on dosage reduction success rate for CML TKI drugs. Very good to see it, even if only a sidelight of a cessation study. 93% is very good success for reduced dosage.

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#5 r06ue1

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LocationEarth, Solar System, Milky Way, Local Group, Virgo Supercluster, Laniakea

Posted 25 January 2017 - 01:24 PM

Will show this to my doc if I ever get to PCRU.

08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

Taking Imatinib 400 mg

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#6 Buzzm1

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Posted 25 January 2017 - 01:57 PM

In hindsight, to help avoid complications caused by the toxicity of these TKIs, especially prevalent in older individuals such as myself, I would advocate for dosage reduction at the earliest, and with every, opportunity, followed by cessation when permitted by continued undetectable status. In my own case I am sorry that I didn't begin dosage reduction three years, or more, earlier. It might have prevented many of the side-effects that I suffered through, including withdrawal side-effects, along with the permanent damage to my body caused by longterm use of Gleevec. The less TKI we take, the better. When afforded the opportunity, reduce your dosage.

For the benefit of yourself and others please add your CML history into your Signature

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.

Cumulative Gleevec dosage estimated at 830 grams

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.

Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt

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#7 gerry

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Posted 25 January 2017 - 05:33 PM

Your Aussie links have some issues working.
http://www.bbc.com/n...d-tyne-38680482

Just to be clear, the 93% success rate was for the reduced dosage, not for cessation.

http://www.onclive.c...merging-for-cml

Thanks Trey - my copy and paste of links seems to cause me issues on this site sometimes, doesn't matter if I am on my phone or PC, I use Chrome on both so not sure if it that.