Basically up update to the June information.
Precision medicine breakthrough for Chronic Myeloid Leukaemia
Issued: Thu, 15 Sep 2016 09:15:00 BST
http://www.gla.ac.uk..._485807_en.html
Precision medicine breakthrough for Chronic Myeloid Leukaemia
Started by
r06ue1
, Sep 16 2016 01:02 PM
CML Cure
6 replies to this topic
#1
r06ue1
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Posted 16 September 2016 - 01:02 PM
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
#2
kat73
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Posted 16 September 2016 - 02:47 PM
Sign me up, sign me up, PLEASE. Will there be trials in the US? Is this Phase 2?
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
#3
Cliffee
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Posted 16 September 2016 - 07:47 PM
Wow! I hope this pans out. Hard to believe though!
#4
Harper3994
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Posted 17 September 2016 - 07:32 AM
Very good news especially for the younger patients. I hope I will be able to benefit from this. If. it turns out well. I wonder if they will allow trials in the u.s.
#5
LAC1223
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Posted 20 September 2016 - 09:37 AM
Amazing - great if they would allow US trials.
#6
beno
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Posted 21 September 2016 - 05:23 PM
The last paragraph seems to run counter to other things I've read.
Dr Áine McCarthy, senior science information officer at Cancer Research UK, said: "We know that when cancer comes back it's a lot harder to treat, and a person's chances of surviving the disease decrease.
I've read nothing elsewhere to suggest what she says is true.
DX 3/30/2016 WBC 484.2 FISH 95.3
took Hydrea 3/30-4/11
taking Sprycel 100 mg since 4/5
10 day break from Sprycel for platelet count of 12 4/26-5/8
7/07/2016 1.47% (IS)
9/30/16 BMB PCR .1259 switched to new onc
12/30/16 PCR .1569
4/7/17 PCR .0904 MMR
7/14/17 PCR .0520
12/1/17 PCR .0148
#7
r06ue1
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Posted 22 September 2016 - 07:29 AM
I believe what the doctor is referring to is when the medication stops working leading to blast crisis or the CML mutates leading to AML/ALL.
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
Also tagged with one or more of these keywords: CML, Cure
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