I had Psoriasis before CML but now with the TKI it is much worse. Now it has spread to under my eyes and ears. Does anyone have this. Just wondering how other people deal with it. I think it is causing my blurry vision. But I am not sure.
Psoriasis and CML
Started by
rcase13
, Aug 31 2016 05:44 PM
2 replies to this topic
#1
rcase13
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Posted 31 August 2016 - 05:44 PM
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg
Cancer Sucks!
#2
Buzzm1
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Posted 01 September 2016 - 12:32 PM
Fortunately you are in a position, or soon will be, where you can begin to slowly reduce your Tasigna dosage if you choose to, 75mg at a time.
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
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#3
AdamJ
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Posted 02 September 2016 - 04:49 AM
While I have not experienced Psoriasis, I can say that I have had blurry vision on both Sprycel and Tasigna so it is possible that the vision issue is unrelated. From what I have found online, the blurry vision seems to be related to water retention. I have found that mine can vary quite a bit and I have been experimenting with different foods to see if I can figure out what might cause the "good vision" days. If I discover anything I will share with the forum. I have increased my potassium intake and reduced the sodium just in case it is related to water retention. Also, I was gradually increased from 50mg Sprycel to 100mg due to my liver toxicity. I definitely experienced less blurry vision on the lower doses so I agree with Buzz's suggestion about dosage reduction. I only wish I was in a position to start considering that, but with < 6 months TKI under my belt, I think I have a long way to go. I hope you are able to find some relief from both the vision and the Psoriasis.
3/23/2016 Dx PCR 93.4399% IS, FISH 87%
3/30/16 Sprycel 100mg
4/15/2016 liver toxicity and a brief stint on Tasigna 600mg book-ended by drug breaks
6/6/2016 resumed Sprycel at 50 mg increased to 70 one month later followed by 100mg
6/17/2016 FISH Test 2%
8/22/2016 PCR 0.0035% IS
11/7/2016 PCRU
12/29/2016 PCRU
4/5/2017 PCRU
6/28/2017 PCRU
10/26/2017 PCRU
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