MMR achieved! Sooooo happy! And on my 25th wedding anniversary, too - what a great gift!
6 Month Checkup
Started by
campanula
, Aug 25 2016 10:54 PM
3 replies to this topic
#1
campanula
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Posted 25 August 2016 - 10:54 PM
Dx 2/16: PCR = 59.4%
BMB showed second translocation.
400 mg generic Imatinib
5/16: PCR = 0.88%
8/16: PCR = 0.04%
11/16 PCR = 0.01%
2/17 PCR < 0.01%
2/17 BMB results: all translocations gone.
6/17 PCR = 0.03%
9/17 PCR = 0.01%
1/18 PCR = 0.01%
#3
Buzzm1
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Posted 26 August 2016 - 01:54 AM
Congratulations campanula! Wishing you continued progress.
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt
#4
r06ue1
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Posted 26 August 2016 - 05:13 AM
Grats!
08/2015 Initial PCR: 66.392%
12/2015 PCR: 1.573%
03/2016 PCR: 0.153%
06/2016 PCR: 0.070%
09/2016 PCR: 0.052%
12/2016 PCR: 0.036%
03/2017 PCR: 0.029%
06/2017 PCR: 0.028%
09/2017 PCR: 0.025%
12/2017 PCR: 0.018%
Taking Imatinib 400 mg
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