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another article released today about why u.s has high drug prices.


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#1 Frogiegirl

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Posted 24 August 2016 - 07:17 PM

http://finance.yahoo...-172518972.html.


Just more excuses. ....

Diagnosed Oct 2013 Started 600mg of Tasigna  on Nov 4th. Lowered dose a few months later to 300mg due to side affects stayed here declining PCR until March 2015 small jump from 0.0072 to 0.0083 scarred my doc into full dose of Tasigna again 600mg(been miserable since) but reached PCRU 06/15/2015(next test) and have been there ever since. Hoping to have another little one. I have the support of my doc to go off anytime, just scared to jump. might go two years PCRU but he said it wont make much of a difference. I just figured I could possibly go into a trial while preggers if I got the two years behind me.

Nov 8th 2017 went off Tasigna

Dec 1st PCRU off TKI

Jan 5th PCR Detected .0625

Feb 1st PCR Detected .7815

Added 8-6 grams Curcumin daily in Feb

March 3rd PCR Detected 3.2646 YIKES!

 stopped trying for baby after February reading. will start new TKI march 16th 2017 (Sprycel)

FYI I'm not done trying for my last little one.


#2 thatguy

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Posted 24 August 2016 - 09:30 PM

It sucks, but hopefully it offers massive incentive for companies to find more effective treatments.
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#3 chriskuo

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Posted 25 August 2016 - 02:51 AM

The article was a news report by Kaiser Health News, which is a respected and objective analyst of health care issues.

 

The excuses relate to the fact that so many Americans have contempt for any kind of regulation but complain about the results when the government is prevented from implementing regulations.

 

The anti-government types that are so predominant in today's politics should be careful what they wish for.

 

The people on this board need to vote down the anti-regulation types if they want to make a difference.  People complaining in this echo chamber makes absolutely no difference.



#4 scuba

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Posted 25 August 2016 - 08:19 AM

From today's Wall Street Journal:

 

http://on.wsj.com/2bBaq3D

 

The article echoes what Frogiegirl posted at the top of this thread. The WSJ article suggests that government creates monopolies in these pharmaceuticals and that's the main driver for the exorbitant prices. My own view is that in order to reverse this trend we need to reduce (not eliminate, but reduce) government control that stifles competition and innovation.

 

Steps to take:

 

1. Allow re-importation of drugs from overseas (that alone will drive prices down).

2. shorten patent protection times from the current 17-20 years to 10 or less.

3. Facilitate generic drug production and competition immediately upon patent expiration.

4. Enable faster drug development and approval outside FDA using fast tracking methods. FDA clinical trials are the most expensive part of the drug pipeline. Once a drug is approved as "SAFE", no reason to subject the same laborious process for that drugs application in other areas and diseases.

 

What we don't want is government takeover and control of the pharmaceutical industry. Artificial price setting will decrease the incentive for innovation and supply. We need the government to facilitate more competition, not less. Any government regulation that will decrease competition and innovation is what should be targeted for change. 


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#5 chriskuo

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Posted 25 August 2016 - 01:16 PM

#1 won't work because drug companies will limit supplies sold into other countries to the amount used internally.
If drugs leak out, it would hurt the foreign patients.

Faster approval by the FDA would be helpful for innovative drugs and newly competitive generics. But that has to be done carefully. Look at what happened with the fast track approval of Iclusig/ponatinib.

The Epipen brouhaha has shown that kids with food allergies get more sympathy in the mass media than adults with cancer.

The biggest problem is that a high percentage of health care costs are paid by employers. The high drug prices are a "rational" response by the drug companies to increase their profits. Then, there is no transparency to all the discounts in the supply chain. Nobody knows who is bearing how much of the cost between employers, insurers, PBM, pharmacies, and patient.

#6 scuba

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Posted 25 August 2016 - 01:46 PM

#1 won't work because drug companies will limit supplies sold into other countries to the amount used internally.
If drugs leak out, it would hurt the foreign patients.

Faster approval by the FDA would be helpful for innovative drugs and newly competitive generics. But that has to be done carefully. Look at what happened with the fast track approval of Iclusig/ponatinib.

The Epipen brouhaha has shown that kids with food allergies get more sympathy in the mass media than adults with cancer.

The biggest problem is that a high percentage of health care costs are paid by employers. The high drug prices are a "rational" response by the drug companies to increase their profits. Then, there is no transparency to all the discounts in the supply chain. Nobody knows who is bearing how much of the cost between employers, insurers, PBM, pharmacies, and patient.

 

All very true ...


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#7 Antilogical

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Posted 25 August 2016 - 02:04 PM

I agree that lack of transparency of drug costs, discounts, and actual payments allows the pharmaceutical industry to get away with setting - and hiking - prices at will.  It also gives insurance companies built-in excuses for dramatic hikes in co-pays.

Here's what I would like to see happen:
1)  Allow Medicare to negotiate drug prices, just like private insurance companies do.
2)  Allow US patients to import drugs from Canada (as a start).
3)  Reduce the patent exclusivity period.
4)  Prohibit payments by patent-holders to generic drug companies that delay the entry of generics to the market when patents expire.
5)  Somehow limit the price of drugs sold in the US by a company that is selling the same drug for much less in other markets.
6)  Require disclosure of costs throughout the supply chain for any drug costing more than XXX.  Start with drugs sold for life-long conditions.


Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.

Rx: 03/2012-Gleevec400.  Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).

Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.


#8 scuba

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Posted 25 August 2016 - 02:19 PM

I agree that lack of transparency of drug costs, discounts, and actual payments allows the pharmaceutical industry to get away with setting - and hiking - prices at will.  It also gives insurance companies built-in excuses for dramatic hikes in co-pays.

Here's what I would like to see happen:
1)  Allow Medicare to negotiate drug prices, just like private insurance companies do.
2)  Allow US patients to import drugs from Canada (as a start).
3)  Reduce the patent exclusivity period.
4)  Prohibit payments by patent-holders to generic drug companies that delay the entry of generics to the market when patents expire.
5)  Somehow limit the price of drugs sold in the US by a company that is selling the same drug for much less in other markets.
6)  Require disclosure of costs throughout the supply chain for any drug costing more than XXX.  Start with drugs sold for life-long conditions.

 

 

6)  Require disclosure of costs throughout the supply chain for any drug costing more than XXX.  Start with drugs sold for life-long conditions.

 

This is a good one - there is a big difference between short term drug need (and cost) vs. a drug serving patients with Chronic conditions in which the drug is life saving (targeted therapies of which TKI's are one). There could be a cap on how long those particular drugs can enjoy patent protection since they are likely taken for life - or some other way to drive competition and multiple vendors. 


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#9 Buzzm1

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Posted 27 August 2016 - 11:53 AM

Most of Congress, if not all, are in the back pocket of  Big PhRMA, the #1 lobbyist in Washington DC. To see any change in drug cost policies, will require harsh action by the voters.  Until then all we will get is mostly lip service.  We have to be willing to vote them all out.  In the meantime you are encouraged to make a continuing and concerted effort to voice your displeasure to each and every member of the Congressional committees responsible for U.S. drug policy:

 

Senate Health, Education, Labor, and Pensions Committee http://bit.ly/11EEmWL

 

House Oversight and Government Reform Committee http://bit.ly/1L7Qek9

 

PS. Don't mince words


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt





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