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Benzene...everywhere!!!

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#1 r06ue1

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Posted 01 April 2016 - 12:32 PM

Benzene...everywhere!!!  

 

I compiled this information from various website to bring awareness (passed it on to friends and family) so wanted to post it on here also.  

 

The stuff is everywhere you look, apparently we have polluted our environment with it to the point where the government (EPA and FDA) even allow you to drink it.  Note in red below where the API says even one molecule of the stuff is not safe to come into contact with.  

 

 

What is benzene?

 

Benzene is a colorless, flammable liquid with a sweet odor. It evaporates quickly when exposed to air. Benzene is formed from natural processes, such as volcanoes and forest fires, but most exposure to benzene results from human activities.

 

Benzene is among the 20 most widely used chemicals in the United States. It is used mainly as a starting material in making other chemicals, including plastics, lubricants, rubbers, dyes, detergents, drugs, and pesticides. In the past it was also commonly used as an industrial solvent (a substance that can dissolve or extract other substances) and as a gasoline additive, but these uses have been greatly reduced in recent decades.

 

Benzene is also a natural part of crude oil and gasoline (and therefore motor vehicle exhaust), as well as cigarette smoke.

 

 

Studies in people

 

Rates of leukemia, particularly acute myeloid leukemia (AML), have been found to be higher in studies of workers exposed to high levels of benzene, such as those in the chemical, shoemaking, and oil refining industries.

 

Some studies have also suggested links to childhood leukemia (particularly AML) as well as acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and other blood-related cancers (such as multiple myeloma and non-Hodgkin lymphoma) in adults. However, the evidence is not as strong for these cancers.

 

There is much less evidence linking benzene to any other type of cancer.

 

Studies done in the lab

 

When inhaled or swallowed, benzene has been found to cause different types of tumors in lab animals such as rats and mice. These results support the finding of an excess risk of leukemia in humans. However, most studies in humans have not found an increased risk of cancers other than leukemia among people with higher exposures.

 

Benzene has been shown to cause chromosome changes in bone marrow cells in the lab. (The bone marrow is where new blood cells are made.) Such changes are commonly found in human leukemia cells.

 

 

Health effects

 

Benzene increases the risk of cancer and other illnesses. Benzene is a notorious cause of bone marrow failure. Substantial quantities of epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute leukemia, and bone marrow abnormalities. The specific hematologic malignancies that benzene is associated with include: acute myeloid leukemia (AML), aplastic anemia, myelodysplastic syndrome (MDS), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML).

 

The American Petroleum Institute (API) stated in 1948 that "it is generally considered that the only absolutely safe concentration for benzene is zero." The US Department of Health and Human Services (DHHS) classifies benzene as a human carcinogen. Long-term exposure to excessive levels of benzene in the air causes leukemia, a potentially fatal cancer of the blood-forming organs. In particular, acute myeloid leukemia or acute nonlymphocytic leukemia (AML & ANLL) is not disputed to be caused by benzene. IARC rated benzene as "known to be carcinogenic to humans" (Group 1).

 

Because benzene is ubiquitous in gasoline and hydrocarbon fuels are in use everywhere, human exposure to benzene is a global health problem. Benzene targets liver, kidney, lung, heart and the brain and can cause DNA strand breaks, chromosomal damage, etc. Benzene causes cancer in animals including humans. Benzene has been shown to cause cancer in both sexes of multiple species of laboratory animals exposed via various routes.

 

Some women who inhaled high levels of benzene for many months had irregular menstrual periods and a decrease in the size of their ovaries. Benzene exposure has been linked directly to the neural birth defects spina bifida and anencephaly. Men exposed to high levels of benzene are more likely to have an abnormal amount of chromosomes in their sperm, which impacts fertility and fetal development.

 

 

Exposure to benzene

 

According to the Agency for Toxic Substances and Disease Registry (ATSDR) (2007), benzene is both an anthropogenically produced and naturally occurring chemical from processes that include: volcanic eruptions, wild fires, synthesis of chemicals such as phenol, production of synthetic fibers, and fabrication of rubbers, lubricants, pesticides, medications, and dyes. The major sources of benzene exposure are tobacco smoke, automobile service stations, exhaust from motor vehicles, and industrial emissions; however, ingestion and dermal absorption of benzene can also occur through contact with contaminated water. Benzene is hepatically metabolized and excreted in the urine. Measurement of air and water levels of benzene is accomplished through collection via activated charcoal tubes, which are then analyzed with a gas chromatograph. The measurement of benzene in humans can be accomplished via urine, blood, and breath tests; however, all of these have their limitations because benzene is rapidly metabolized in the human body.

 

OSHA regulates levels of benzene in the workplace. The maximum allowable amount of benzene in workroom air during an 8-hour workday, 40-hour workweek is 1 ppm. Because benzene can cause cancer, NIOSH recommends that all workers wear special breathing equipment when they are likely to be exposed to benzene at levels exceeding the recommended (8-hour) exposure limit of 0.1 ppm.

 

 

Benzene is found in the air from emissions from burning coal and oil, gasoline service stations, and motor vehicle exhaust.

 

 

Natural Processes That Produce Benzene

 

Volcanoes

Forest fires

 

 

Products Containing Benzene

 

Paint, lacquer, and varnish removers

Industrial solvents

Gasoline and other fuels

Glues

Paints

Furniture wax

Detergents

Thinners

Inks

Adhesives and coatings

Rubbers

Industrial cleaning and degreasing formulations

 

 

Activities/Uses Involving Benzene

 

Emissions motor vehicle exhaust

Burning coal and oil

Painting and lithography

Dry cleaning

Making chemicals used to make:

Plastics

Resins

Nylon and synthetic fibers

Making some types of:

Lubricants

Rubbers

Dyes

Detergents

Pharmaceutical drugs

Agricultural chemicals (pesticides)

 

 

Industries Using Benzene

 

Petrochemical manufacturing

Petroleum refining

Coke and coal chemical manufacturing

Rubber tire manufacturing

Gasoline storage, shipment, and retail operations

Plastics and rubber manufacturing

Shoe manufacturing

 

 

Occupations/People Who May Be Exposed To Benzene

 

Steel workers

Printers

Rubber workers

Shoe makers

Laboratory technicians

Gasoline service station employees

Places Where Benzene May Be Found

 

Air around waste sites and gas service stations

Contaminated well water, as a result of benzene leaks from underground storage tanks or hazardous waste sites containing benzene

 

 

Component of gasoline

 

As a gasoline (petrol) additive, benzene increases the octane rating and reduces knocking. As a consequence, gasoline often contained several percent benzene before the 1950s, when tetraethyl lead replaced it as the most widely used antiknock additive. With the global phaseout of leaded gasoline, benzene has made a comeback as a gasoline additive in some nations. In the United States, concern over its negative health effects and the possibility of benzene's entering the groundwater have led to stringent regulation of gasoline's benzene content, with limits typically around 1%. European petrol specifications now contain the same 1% limit on benzene content. The United States Environmental Protection Agency introduced new regulations in 2011 that lowered the benzene content in gasoline to 0.62%.

 

 

Benzene found in soda

 

In November 2005, the Food and Drug Administration (FDA) received private laboratory results reporting low levels of benzene in a small number of soft drinks that contained benzoate salts (an antimicrobial) and ascorbic acid (vitamin C). FDA has no standard for benzene in beverages other than bottled water, for which FDA has adopted the US Environmental Protection Agency (EPA) maximum contaminant level (MCL) of 5 ppb for drinking water, as a quality standard.


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#2 Melanie

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Posted 01 April 2016 - 04:14 PM

Scary information. Interesting enough my exposure to all those things has always been very limited, so I don't think that's a cause for my CML. I'll definitely be wary of it though and thanks for the info.

 

Melanie 


Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)

#3 gerry

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Posted 01 April 2016 - 06:05 PM

I don't consider it a cause for me for CML. I have my own thoughts as to why it happened and why I am now off TKI.

#4 thatguy

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Posted 01 April 2016 - 06:34 PM

First thing they asked me in the hospital at diagnosis. "Exposure to benzene, chemicals like gasoline and motor oil? " ... well yeah, worked in a Toyota shop for 3 years up to 53 hours a week. Common playful activity was Brake-kleen fights using the (xylene or toulene that came in bulk 55 gal drums that was stored in a back open room in the shop). Common advice- "oh you're bleeding, spray some Brake-Kleen in it to stop the bleeding" oily skin? Spray brake kleen on it.....no idea how toxic this stuff was proven to be. And it's in everything else too, practically. Sodium benzoate when combined with ascorbic acid supposedly forms it too. Read your soda and energy drink labels.
3/25/2015- Dx'ed by FISH : 85% of cells dual-fusion signals, 7% with tri-fusion signals, WBC 212,000. Started Gleevec 400mg.... Calculated .93 SOKAL

08/17/2015- 14.793 % I.S P210 (quest)
10/15/2015- 3.313 % I.S (quest)
12/23/2015- 1.891 % I.S (quest)
1/07/2016- Tasigna 300mg 2x daily
1/14/2016- 4.414 % I.S P210- City Of Hope lab, mutation negative.
1/26/2016- 1.589 % I.S (quest)
2/22/2016- 1.719 % I.S (quest)
2/29/2016- 1.133 % I.S (quest)
3/03/2016- Tasigna 400mg 2x daily.
3/29/2016- 0.663 % I.S (quest)
4/27/2016- 0.781 % I.S (quest)
5/04/2016- 0.652 % I.S.(quest)
5/24/2016- 0.501 % I.S (quest)
6/28/2016-0.534 % I.S (quest)
7/15/2016-0.881 % I.S (quest)
7/22/2016- Bosulif 500mg
7/28/2016- t315i test- Negative
8/22/2016-0.432 % I.S (quest )
11/15/2016-0.325 % I.S (quest)
2/1/2017- .0445% i.s (genoptix)
5/6/2017- .0968% i.s (genoptix)
5/12/2017- .12 % i.s (quest).
6/4/2017- .083% i.s (quest)
6/11/2017- .0295% i.s (genoptix)
8/5/2017- .0501% i.s (genoptix)
11/6/2017- .0270% i.s (genoptix)

#5 winespritzer

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Posted 02 April 2016 - 06:26 AM

Thank you very much for all this info. More than ever I think there's a correlation between my cml and 9/11. I can still remember that sweet/acrid odor I smelled every morning when I crossed the bridge into NY from NJ or when I walked outside. Several colleagues also now have cml or multiple myeloma. Some w mm have passed away. We weren't in the clean up zone but within walking and smelling distance of the towers. And definitely where the cloud filled wind coated our building sites,selves and cars w the terrible ashes.
I also drove yrs down a highway to the Holland Tunnel that reeked of benzene...

However my onc thinks there's no correlation or reason to think about causality. My husband's pulmonologist thinks otherwise as did a Dr I consulted in NYC for a facial rash days after the havoc.

Alas, I thank this site and Sprycel.
Winespritzer

CML History....

DX-1/14....wbc....55....100mg Sprycel-1 wk after DX....periorbital edema, fatigue,

.385-4/14

.365-7/14

.13-10/14

.11-1/15

.045-4/15

.07-7/15

.06-10/15

.04-1/16

0.00- 4/16-10/17

 

70mg Sprycel...11/4/17....40 mg prednisone (7 days)....thoracentisis...10/26/17

tremendous reduction w periorbital edema and fatigue


#6 r06ue1

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Posted 02 April 2016 - 04:22 PM

I truly believe that this is the major cause of leukemia worldwide.  We have polluted our planet to such an extent that we even think this is normal which is truly sad.  How else does one explain little kids, even babies, getting leukemia?  Has to be our environment and all of the chemicals we have dumped into it.


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#7 Lisa Lisa

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Posted 06 April 2016 - 08:54 PM

Winespritzer - I also believe 9/11 played a part in my CML. (Benzene and toxic chemicals).
I worked at One Liberty, directly across the street from the World Trade Center. My company was evacuated from the building and then incredibly after just two months, we were back to work. the ductwork never cleaned it was verified. Since 9/11 30 of the 55 people in my department have developed a cancer. Thats an incredible statistic.

Dx 2/2015 BCR-ABL1 (p210) 85.2% (IS) 3/15

     22%  5/15     0.13% 6/15   PCRU attained 9/15

Initial dose Sprycel 100 mg 3/15  Lowered 80 mg 5/15   Lowered 50 mg 1/16

Note: dose lowered bc of side effects - not bc onc wanted to reduce dosage

Sprycel: Currently 50 mg per day - taken 10 pm

 


#8 r06ue1

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Posted 07 April 2016 - 08:14 AM

Hi Lisa, 

 

What's more sad is that so many carcinogenic materials was used in the construction in the first place.  ;) 

 

You voting for Bernie in a few weeks?  :)


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#9 Lisa Lisa

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Posted 14 April 2016 - 07:24 PM

Hi r06ue1,
Im very disappointed in the candidates.
Yes many carcinogenic materials were used. Terribly sad.

Dx 2/2015 BCR-ABL1 (p210) 85.2% (IS) 3/15

     22%  5/15     0.13% 6/15   PCRU attained 9/15

Initial dose Sprycel 100 mg 3/15  Lowered 80 mg 5/15   Lowered 50 mg 1/16

Note: dose lowered bc of side effects - not bc onc wanted to reduce dosage

Sprycel: Currently 50 mg per day - taken 10 pm

 


#10 r06ue1

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Posted 19 April 2016 - 09:21 AM

Wow!  Scary stuff!  And it is in a lot of our foods and drinks.  

 

 

Sodium benzoate is a synthetic chemical produced when benzoic acid, which is found naturally in some fruits and spices, is combined with sodium hydroxide. Since sodium benzoate contains a natural ingredient, it is probably safe, right? After all, the US Food and Drug Administration (FDA) and the Canadian Health Protection Branch have pronounced this chemical preservative to be acceptable when consumed in low amounts.

In fact, the FDA has granted sodium benzoate GRAS (Generally Recognized as Safe) status, and the so-called safe limit in food is 0.1 percent by weight. In water, the acceptable limit, set by the Environmental Protection Agency, is 5 parts per billion (ppb). But this common food additive, which is found in carbonated sodas, fruit juice products, salad dressings, and fermented foods such as vinegar, wine, and pickles, is not natural nor safe. Here's the story.

Sodium benzoate is a sodium salt that is present at extremely low levels in berries, apples, plums, cinnamon, and several other natural foods. There's nothing scary about the chemical in these items. But lab-synthesized sodium benzoate (and its close relative, benzoic acid) are a different story. When these preservatives are added to foods and to the interior of metal cans that contain beverages or liquid foods, they can have a detrimental effect on your health.

For example, a small percentage of people are hypersensitive to sodium benzoate and can experience asthmatic attacks, hives, or other allergic reactions when they consume the preservative. A more common problem, however, is the combination of sodium benzoate and citric acid and/or ascorbic acid (vitamin C). When these ingredients get together, they form benzene, a cancer-causing chemical associated with leukemia and other blood cancers. 

- See more at: http://naturallysavv...h.9dqxozY5.dpuf

 


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#11 r06ue1

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Posted 19 April 2016 - 09:35 AM

More on Sodium Benzoate:  

 

https://www.youtube....h?v=IeCPVIFFk7w


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#12 r06ue1

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Posted 19 April 2016 - 11:06 AM

 

 

Sodium benzoate is not known to be carcinogenic on its own.  However, there have been concerns by the FDA that when both vitamin C (ascorbic acid) and sodium benzoate are mixed, they form benzene, a known human carcinogen.  Benzene is also formed when potassium benzoate is combined with vitamin C.  Shelf life and exposure to high temperature or light affect the rate that benzene is formed.    

 

https://thehealthrep...odium-benzoate/


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#13 r06ue1

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Posted 17 February 2017 - 12:35 PM

Lots of dump sites around America, some just now being discovered that homes, apartments and schools have since been built upon.  Many of these dump sites go back to WWII.  

 

https://www.google.c...nzen dump sites


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg






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