Posted 23 March 2016 - 01:16 AM
Did I read it correct that only 40% to 50% reach MR4.5? If so that is depressing.
You're referring to: "But the reality is that the percentage of patients that reach these sustained MR 4.5s, even with second-generation TKIs, is at best 40%, 50%. So, there's still a significant number of patients who don't quite make it to those criteria for treatment discontinuation, and that's where there's an interest in can we do something else to push them to that level. - See more at: http://www.onclive.c....Q2BAU6m2.dpuf"
That sounds more like a reference to the percentage of people who are able to successfully discontinue TKI's without relapse ... one of the problems is that there are any number of patients who have been PCRU for many years and they are still on full dosage; they haven't yet attempted to lower their dosage, let alone make an attempt to discontinue their TKI. IMO, that's what needs to change ... Earlier encouragement by Oncs to lower your dosage, and cease TKI's if at all possible.
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
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