Posted 15 March 2016 - 10:29 PM
Elvis, being that you were already MMR, I am surprised that your Onc didn't have you take a drug break and then lower your Sprycel dosage to 50mg. As Melanie mentioned you should not be required to start Bosulif at full dosage (500mg) .. you've been through the wringer .. 600mg Gleevec when the standard dosage is 400mg; 800mg Tasigna when the standard dosage is 600mg; and then 100mg Sprycel; I can't blame you for feeling a little anxious ... after all that we would all be anxious.
Be willing to argue the case for a lowered dosage ... I think one of our members started Bosulif at a greatly reduced dosage and has had good luck with it ... he'll be on later to fill you in. Here's a post by him http://bit.ly/1Pb4gTb
Good Luck to you ...
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
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