The generics vs Gleevec
Posted 29 January 2016 - 01:13 AM
there is no shortage and number of generic Gleevecs available http://bit.ly/1vvuCg3
while the efficacy of at least some generics may differ, the cml-iq.com article: Generic Gleevec - Is the same the same? http://bit.ly/1PmkCNm creates more questions than it answers.
In reference to the release of the U.S. Gleevec generic on 02/01/2016, there isn't any justification for the alleged introductory pricing at 80% of the patented Gleevec, whose price has been increasing up to 20% a year in the U.S., ever since it was first introduced in 2001. It's called whatever the traffic can bear. It doesn't help that the U.S. Congress is in the back pocket of Big PhRMA.
I last priced patented Gleevec in August, 2015 at Kaiser .. slightly over $132,000/yr for the standard 400mg dose.
In as much as Novartis coordinated with Sun Pharma on at least, the release date, and likely the pricing, there is likely to be very little difference. if any, between Sun's generic Gleevec and the patented product, especially with the U.S FDA involved http://bit.ly/1Kev5ua. ...
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
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