Posted 23 January 2016 - 05:56 PM
Solving Pharma's Shkreli Problem http://onforb.es/1OFIom3
far down in the article:
Take the case of Novartis' Gleevec, a lifesaving pill that puts a deadly cancer called chronic myelogenous leukemia out of business. It was introduced in 2001 at a cost of $24,000 per patient per year. Then, in 2006, Bristol-Myers Squibb introduced another drug, Sprycel, for patients who had failed on Gleevec. When Novartis introduced its own successor to Gleevec, it was marketed (at first) to the sick patients treated with Sprycel. So it priced the drug to compete with Sprycel and raised the Gleevec price. The result: Gleevec now costs more than $90,000 a year. (actually over $120,000 a year)
to think that U.S. generic Gleevec ((being introduced on 02/01/2016) will cost far more than the original price of the drug
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
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