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Tasigna to Gleevec Transition - Need advice

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#1 bagdaddi


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Posted 08 December 2015 - 08:11 PM

Hi Everyone,


Long story that I don't want to go into now, but am about to switch from the following and would appreciate any advice on how to transition.


March 2012 - November 2015  Tasigna (600 mg/day)

December 1-10 2015 Tasigna (300 mg/day)

December 10-? Gleevec (400 mg/day)


Tolerated Tasigna well and have been in sustained low MMR, but had four small strokes and spent 3 days in the hospital over Thanksgiving.  46, active, no family history of stroke, ok cholesterol, non-smoker.  60-70% stenosis of both carotids in the siphon.  Neurologist is perplexed.  



#2 bagdaddi


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Posted 08 December 2015 - 08:22 PM

For those interested - wish I had reacted sooner:



#3 rcase13


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Posted 08 December 2015 - 09:37 PM

For those of us on Tasigna what test should we be having? I get EKG every three months and Echo done once a year. Is there more I should do?

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg


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#4 Grateful9771


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Posted 08 December 2015 - 11:24 PM

Hello John, 


I suspect Gleevec will be a vast improvement for you with regards to the potential of VAE's.  I have been on Gleevec for 6 years now with great success.   I am overweight, have to watch my cholesterol and blood pressure.  In fact I am on medications for both of those as well.  A friend of mine is on Tasigna.  When I am at her house, an alarm will sound and she will say, "It's been 2 hours since I ate, I can now take my medication."  Yew,  that sounds like so much work.   Best Wishes for Great Success with the Gleevec! 

#5 Buzzm1


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Posted 09 December 2015 - 12:51 PM

Sorry to hear about your problems while on Tasigna John.


Take Gleevec with your heaviest meal of the day.  Personally, after experiencing stomach problems, I did better taking Gleevec one hour after dinner.   



For the benefit of yourself and others please add your CML history into your Signature


02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive


2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17


At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  


In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  


longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.


Cumulative Gleevec dosage estimated at 830 grams


Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  


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#6 Karen06410


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Posted 09 December 2015 - 06:16 PM

Hi John:  I have been taking Gleevec since June 2014, when I was diagnosed.  Since I have heart problems AF and am overweight as well, my dr. said Gleevec is the best one to take for heart conditions or for the heart for that matter.  Thankfully I haven't had any side effects from it, accept upset stomach, but it is better now, and especially if you eat something when you take it.  I think you will do fine with Gleevec.  How long have to had CNL?  What is your PCR#?  I will be praying for you to be able to easily adjust to the Gleevec.

#7 Trey


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Posted 10 December 2015 - 08:05 PM

The vascular issues seem to be more important for Tasigna users than QT elongation, from my observations. 

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