I decided to resume taking 20mg Sprycel (at my wife's urging) even though I am below MMR during my cessation trial and was authorized and encouraged to continue.
My reason had to do with a somewhat sudden infection that I developed a few weeks ago that grew into a chronic cough and neck soreness. This is the first time I have had any illness whatsoever since diagnosis and reminiscent of my first ever pneumonia that I am confident was CML related (weakening immune system). My thinking is that my neutrophils are not of good quality as before. Even though my PCR's are holding steady, I can't help but feel that CML is reasserting itself albeit very very slowly. I needed to see my PCR fall back after the initial rise and loss of PCRU. And they didn't.
So - I decided to start Sprycel again out of curiosity and test that my PCR does in fact fall back (even to PCRU). I will resume cessation if my PCR drops back and will try this on again off again strategy.
Trey wins the bet. I didn't go a year without Sprycel. Nine months wasn't bad. I just want to see and confirm that TKI resumption reverts me back to PCRU. If it does, I will try cessation again. ... and again ... and again ... I won't give up this effort. Something tells me it can work once the leukemic stem cells burn themselves out which is a theory to which I subscribe. And even though my immune system may be keeping CML in check - it's not without a weakened immune system.
Thanks to the Forum for all of your support.
p.s. The first time I resumed taking sprycel (about a week ago) - big headaches. I hate these drugs. But the headaches faded within a couple of days. No other side effects I can feel. That's good news on such a low dose.