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Keep the best, throw away the rest ... or should I just average?

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#1 Buzzm1


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Posted 21 October 2015 - 01:23 PM

Went in for my Onc CML quarterly blood test yesterday coupled with my PCP blood tests in advance of my Oct. 30 annual physical.


The person checking me in ran off six barcoded labels and I proceeded to the blood draw area.


The check-in person brought a seventh label for me into the blood draw area.


The technician preparing to do the blood draw noticed that there were two CBC labels, one for each doctor, so she pulled one of the CBC labels, and wrote a note that the results should go to both doctors.


Nevertheless they processed two CBC's, along with two of most everything else  ... and the results were slightly different on most all of the tests and markedly better on some of the tests,  ... so, do I get to pick and choose the best, or should I just average?


WBC was 10.1 on one and 10.6 on the other

Platelets 344 and 297

Glomerular Filtration Rate 60 and 56

Creatinine 1.19 and 1.25


term this "the luck of the draw"


both results in all cases were entered into my medical record history.










For the benefit of yourself and others please add your CML history into your Signature


02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive


2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17


At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  


In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  


longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.


Cumulative Gleevec dosage estimated at 830 grams


Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  


Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

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#2 tammielee



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Posted 21 October 2015 - 05:08 PM

Yes that's odd. But sometime the machines that do these test are not calibrated the same. So that's why it little off. I shot for the middle of the two.  Just wait for the next lab draw results. 

#3 Trey


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Posted 21 October 2015 - 06:42 PM

I have said this many times, that two blood tests (CBC, PCRs, or whatever) on the same sample will yield different results.  So on two different vials it is even more pronounced. 


People should especially note the differences in your two Platelet counts.  That is a very large difference between the two CBCs, which should be instructive that the PLT test is especially prone to errors.

#4 Melanie


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Posted 24 October 2015 - 06:35 PM

To echo what Trey said above...I have my platelets tested two different ways every lab test. One in the CBC anf the other in a special citrate tube. They always come back different and the citrate tube is usually a bit higher. Last test showed platelets on the CBC as 82 and on the special citrate test as 105. Which one do we use as reference... The one that shows the best result of course!
Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)

#5 R0f03l


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Posted 25 October 2015 - 01:22 PM

Can be a laboratory problem.I do not worry too much about it

#6 Terran


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Posted 26 October 2015 - 10:35 AM

You should average. But definitely take Trey's advice and notice the relative percent difference. Some analyses are very precise and some are more of a guestimation. I think some labs report way too many significant figures. For example, both platelet results round to 300. Anyway, make a mental note of which test numbers should be taken "with a grain of salt" and you'll know not to get excited if those fluctuate a bit.

#7 soundoff


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Posted 28 October 2015 - 01:52 AM

Brain dead people working in the labs. Hilarious

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