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Gleevec Potency Lost?

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#1 jlegakis


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Posted 03 October 2015 - 02:24 PM

Hi Everybody! I was wondering if keeping your Gleevec in your car could affect its potency-especially with the warm summers ! My tests  show progress as my PCR is at 4% after 17 months past dsx., so I guess it has not decreased my dosage efficacy... or has it?? I keep my 400mg. on my desk and take that when I wake up, but later in the day at suppertime I take the additional 200 mg that I keep in my car since I`m out all day with my job. Any advice? Also, since it is ,of course, a monthly prescription would potency be lost that fast  anyway -I`m onto my next prescription !

#2 dchicago



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Posted 03 October 2015 - 06:11 PM

It's not recommended to store Gleevec in high temperature.  If the pharmacy is being careful in sending the medication in cool packs during the summer, I would be careful storing it too.  There was one time during travelling, I left my back pack in the car.  I have a small number of pills I needed for the trip in the back pack.  I don't know whether it affected its efficacy, but the brown coating of the pills cracked after an afternoon in the hot car trunk.


I typically carry my pills I need for the day in a pill case on my key chain inside my pocket.  Keeping the rest at home at room temperature.  While the temperature inside my pocket maybe higher than the recommended storage temperature, I figured I'm only carrying it for several hours before taking it.  Shouldn't do too much damage.

#3 Buzzm1


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Posted 03 October 2015 - 07:10 PM

From a previous discussion:


For the benefit of yourself and others please add your CML history into your Signature


02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive


2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17


At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  


In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  


longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.


Cumulative Gleevec dosage estimated at 830 grams


Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  


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#4 Trey


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Posted 04 October 2015 - 09:41 AM

Any losses are minimal unless it is over a long period of time.

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