Hi. I will start gleevec tomorrow for newly diagnosed cml. I provide nursing care for newly pregnant women. Oncology nurses I've worked with had to switch to other types of nursing when they found they were pregnant. The patient insert that came with the gleevec said it's very harmful to early pregnancy. Also said anyone handling the drug should wash hands well. Does anyone know if my being on gleevec has the potential for harm to my patients? BTW. I'm way too old to become pregnant myself!
Exposure of pregnant women to my gleevec
Started by
Gail's
, Feb 01 2015 05:42 PM
22 replies to this topic
#1
Gail's
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Posted 01 February 2015 - 05:42 PM
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#2
Red Cross Kirk
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Posted 01 February 2015 - 07:39 PM
The only way I can think of harm coming to your patients from your Gleevec is if you gave them a blood transfusion using your own blood. 
I used to regularly donate blood to the Red Cross, but for some reason they don't want my blood any more. 
Kirk
9/25/2012 p210 transcript 118.7% IS @ Dx, begin Gleevec 400mg/day
12/2012 3.59% & bone marrow biopsy - no residual myeloproliferative features but detected 1/20 metaphases containing the Philadelphia chromosome
2013 0.914%, 0.434%, 0.412%
10/2013 0.360% & bone marrow biopsy - normal male karyotype with no evidence of a clonal cytogenetic abnormaltiy
2014 0.174%, 0.088%, 0.064%
2015 0.049%, decrease to Gleevec 200mg/day, 0.035%, 0.061%, 0.028%
2016 0.041%, 0.039%, 0.025%
2017 0.029%, 0.039%, switched to generic imatinib 200mg/day, 0.070%, 0.088%
2018 0.233%
#3
Trey
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Posted 01 February 2015 - 10:57 PM
The issue is pregnant women crushing and handling the crushed/broken form of the drug. For some strange reason pregnant women enjoy doing that. Odd, but I just report the facts. It takes all kinds.......
#4
Billie Murawski
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Posted 02 February 2015 - 12:22 AM
When a pregnant woman is in labor she will grab and crush Anything within her reach!
#5
Gail's
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Posted 02 February 2015 - 01:40 PM
Ha ha to Trey and Billie. I asked my dr this question and found out the body fluid where gleevec is most likely to be found is urine. So as long as I don't bleed or pee on my patients, it should be fine. Don't plan on doing either of those any time soon!
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#6
Marnie
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Posted 02 February 2015 - 07:14 PM
It's always good to hear that docs and nurses don't pee on their patients.
#7
Antilogical
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Posted 02 February 2015 - 08:38 PM
Once again, I must post this warning: DO NOT READ THIS BLOG WHILE DRINKING A GLASS OF ANYTHING. You will be in cleanup mode for a while....
Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.
Rx: 03/2012-Gleevec400. Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).
Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.
#8
Trey
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Posted 02 February 2015 - 08:56 PM
Maybe there should be a warning on the bottle:
"Caution: Do not urinate, defecate, spit, or otherwise expel (including but not limited to zit popping) TKI on pregnant women. Anyone else is fair game."
#9
Marnie
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Posted 02 February 2015 - 10:21 PM
As I seem to recall from my Gleevec days. . .and from conversations with PhilB. . .sometimes a person just can't help expelling things. Forcefully. Without warning. 'Nuff said.
#10
hannibellemo
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Posted 03 February 2015 - 07:56 AM
Ahh, yet another day begins with witty CML repartee. I love this group!
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
#11
Billie Murawski
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Posted 03 February 2015 - 11:53 PM
Ahh, yet another day begins with witty CML repartee. I love this group!
Hi Pat, Did you see where Marnie has more bikes than old Mother Hubbard had kids, boy she must have a hell of a retirement plan. What I can't figure out is why she buys bikes that all look the same.
#12
Gail's
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Posted 04 February 2015 - 08:29 PM
You guys crack me up! Really, Trey, zit popping??? I've only been on gleevec 3 days and I'm so tired today I came home early to nap. I don't know if it's all in my head or if the med could be making me more tired already.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#13
Billie Murawski
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Posted 05 February 2015 - 12:52 AM
Hi Gail,
Fatigue seems to be at the top of everybodys list of side-effects, I'm over 7 years since dx (of course that doesn't have anything to do with being 7 years older) it's definitely not in your head. Some people conquer the fatigue, not me I sleep through it! I'm on other meds that cause fatigue so I feel like I don't have a chance. Just once I'd like a pill that says may cause energy 
! Right now I'm on 2 different bp meds and they are knocking me on my arse. Even my water pill says may cause tiredness isn't that special I take these meds to calm me down and lower the bp, but I have to pee every 10 minutes can I count that as exercise? Being retired,stuck in the house,in the country,in the winter,with a recuperating husband, just typing that makes me tired.
I have picked up a terrible habit, every night I dose off about 7:00 pm for a couple hours then I'm awake until the wee hours of the morning. I gotta stop that. I have a treadmill and I do get some exercise when I dust it.
You're an active person so I'm sure you won't let the fatigue get to you. It takes awhile to adjust to these meds, we call it the new normal but thank God we have a treatment now it wasn't to long ago there wasn't any treatment for cml. I have 2 wonderful kids (adults) and 2 precious grandsons and I'm so thankful to be here to enjoy them.
The best advice I can give anybody is Never lose you're sense of humor!!! That's what keeps me going no matter how bad things get. I can't help myself I'm Irish. Take care Billie
#14
Gail's
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Posted 05 February 2015 - 09:31 PM
Do you remember, Billie, how quickly the fatigue worsened after you started on meds? I an
M trying to sort out what's caused by the disease or med and what could be emotional reaction to this. I too am very grateful to have help to live a nice long life.
M trying to sort out what's caused by the disease or med and what could be emotional reaction to this. I too am very grateful to have help to live a nice long life.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#15
Billie Murawski
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Posted 06 February 2015 - 01:38 AM
Gail, I'm not a good person to ask because I have some other health problems and I take meds they all say may cause drowsiness. I just answered a post to you and I was thinking you started on Sprycel. You started on Gleevac? At first just the dx alone had a serious emotional impact on me and all of us. That is totally normal. I'm over 7 years since dx,and sometimes I forget I have cml especially if I have other stressful things going on,but in the back of my mind it's always there, I guess I reached a point of acceptance,once I found this group. I felt so alone for 3 years, I had no support at all. Having all these wonderful people around me put my mind at ease so many times, just when I get a good obituary written for myself,they keep telling me I don't need it. They are always right. I got another obit going I'm trying to figure out what I did with my life. I've been a singer,dancer,musician,world wide traveler,philanthropist,maybe in this obit I'll be something slutty.The newspaper will print anything as long as they get paid. Billie
#16
klf2013
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Posted 06 February 2015 - 10:32 AM
Hi Gail, Fatigue was a problem for me prior to diagnosis. That was what caused me to get checked out. When my CBC normalized, I noticed I was not as tired as prior to diagnosis, however, "the new normal" did set in. Your body is acclimating to the medication, so I would say you might be more tired now...but eventually it should even out. Nap when you need it. It helps your body heal. Isn't that what you tell your new moms? 
#17
Gail's
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Posted 07 February 2015 - 02:50 PM
For a hyper person like me the fatigue is really annoying. Yes, KLF, that's exactly what I tell my patients. And exactly what my friends are telling me. Have to pay my bills and keep my good insurance. Work is stressing me more than usual. Naps during lunch help. Would love to find a way to fast forward to retirement. Anyone found that button yet?
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#18
PhilB
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Posted 08 February 2015 - 12:42 PM
This is my fast forward to retirement button: http://www.mrmoneymustache.com
Coming on here, however, reminds me very strongly how lucky I am to come from a country where I don't have to worry about copays and medical insurance and I really feel for the majority on here who seem to struggle more with the financial than the medical aspects of CML.
#19
Antilogical
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Posted 08 February 2015 - 05:09 PM
On the other hand, your country gave us Scary Spice and One Direction. I blame them for my illness. CHECKMATE, MelB PhilB, checkmate!
Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.
Rx: 03/2012-Gleevec400. Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).
Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.
#20
Billie Murawski
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Posted 08 February 2015 - 06:44 PM
This is my fast forward to retirement button: http://www.mrmoneymustache,com
Coming on here, however, reminds me very strongly how lucky I am to come from a country where I don't have to worry about copays and medical insurance and I really feel for the majority on here who seem to struggle more with the financial than the medical aspects of CML.
I can't click on to PhilBs external link, am I missing something?
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