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#1 judyann


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Posted 14 September 2011 - 07:49 PM

I have had CML for almost six years and have yet to reach PCRU.  My August 23 PCR was 0.008.  I am currently taking Sprycel 100mg (after 5 1/2 years of 600mg Gleevec).  Question:  Is it logical to thing that if I was to take 140mg of Sprycel each day I could reach PCRU?  Just asking . . . .  Thanks!  JA

#2 Marnie


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Posted 14 September 2011 - 07:54 PM

Hi, Judyann. .

Yes, it's a logical question.  I'm certainly not an expert, but here are some things to consider:

140 mg of Sprycel is the dosage used for accelerated phase

140 mg puts you at higher risk for pleural effusion (I believe).

When my PCR counts went up, my oncologist went spastic and wanted to up my dosage from 100 mg to 140.  Initially, I agreed with him. . after all, he's supposed to be the expert. But after hearing comments on the forum, and doing some research, I decided to keep my dosage at 100  mg and switch docs.

Your situation is different than mine, but in any situation, it's important to be sure that you have as much information as you can get before you make an informed decision.

Good luck,


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