I was diagnosed with cml in June 2006. On December 31, 2006 my pcr came back 0:100000. I have traveled quite a bit, living in several different areas of eastern U.S. I have been seen by 4 different doctors(Lexington, KY, Charleston, SC, and Nashville, TN). My 6month pcr's were all 0:100,000 until 18 months ago. February 2010 was 0:100,000, August 2010 was 1:100,000, February 2011 was 1:100,000 and the most recent was 4:100,000. The last 3 test were run and Vanderbilt University Lab. What is the margin of error for the pcr for bcr? At what point should one become concerned?
pcr margins of error
Posted 25 August 2011 - 04:06 PM
I do not know why these would even be reported as numbers. Normally the report should say: "positive but below the level of quantitation". The error rate for the BCR-ABL PCR can be up to 1/2 log. You might want to try a different lab just to confirm if your Onc can do that.
Posted 25 August 2011 - 08:32 PM
I have used 4 different labs over the last 5 years and they all report it quantitatively e.g. 1/100,000 = .00001 with an explanation that the finding indicates progression free for subsequent 12 months. I have looked at all by pcrs dating back to diagnosis and they all read that way, from 4 different labs
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