Posted 01 July 2011 - 02:09 AM
The dose thing wrt size was discussed with me too but from the smaller weight perspective. It makes sense but there is not much data on it. I remember reading some Japanese research that showed that Japanese (on average smaller) suffered more side effects on a given dose compared to Westerners.
800mg is the max dose. I asked my hem if I could go from 600 to 800 to try and get a quicker reduction (we don't have access to the 2nd generation drugs as frontline) but she said that many people on 800 have to take drug breaks and it is more efficient to maximise the dose you can handle without breaks. It was a crazy thing to ask because I have enough side effects on 600. There was a paper that looked at the dose average for people on 800 and over some months they actually averaged close to 600. None of this takes weight (prob should be lean muscle mass) into account. At 6 6" you are clearly not average - airline travel must be horrible.
I've seen some discussion here about reducing dose once PCRU and it seems like a suck it and see thing. Does anybody know if there is any research on reducing dose after PCRU?
Dx Dec 2010 @37
2x IVF egg collection
Glivec 600 & 800mg
PCRU March 2012
Unsuccessful pregnancy attempt - relapsed, 3 months interferon (intron A), bad side effects from interferon
Nilotinib 600mg Oct 2012
PCRU April 2013, 2 years MR4.5 mostly PCRU with a few blips
April 2015 stopped again for pregnancy attempt (donor egg), pregnant first transfer, 0.110 at 10wks, 2.1 at 14wks, 4.2 at 16wks, started interferon, slow dose increase to 25MIU per wk, at full dose PCR< 1 for remainder of pregnancy
Healthy baby girl Jan 2016, breastfed one month
Nilotinib 600mg Feb 2016
MMR May 2016
PCRU Feb 2017