I don't know if I have false memory syndrome, but I remember hearing that if your reach CCyR, there would be a 2 log reduction in your PCR. Since it doesn't look like I had a 2 log reduction yet, I assume this is not true. I am just asking because I will be relying on PCRs to shed light on the cytogenics until I have my next BMB in May.
Although, I was first diagnosed just over a year ago, I didn't have a reliable PCR until last May.
5/10 13.739% (had another one done a few days later that read 9.378---That seems like a big flux; so what looks like a log reduction to me could not be one)
8/10 4.921% (this number is where my onc thought I wasn't making good progress on Gleevec and switched me to Sprycel)12/10 1.334% (on Sprycel 3 months--doesn't look like miracle progress, but it is lower)
From my limited understanding of log reductions, although I see no zeros, the difference between 13.739 and 1.334 is greater than 10. So, I think this would be 1 log down. Does this look like an average response or am I still considered a slug?
P.S. LabCorp does the PCR. I am still unsure what the lab control is. So I don't know the disease burden, like, if these numbers are sky-high, low, or just average. I just got my molecular report back and it said this time that in 3% of CML patients, the gene fusion occurs without cytogenic evidence of rearrangement (guess that would be PH- CML).
Here are my questions to make it easier:
1) Did I have a log reduction?
2) What is the common margin or error for PCR testing? Could you provide a sample?
3) Do you need to see zeros for a log reduction (if answer to 1 is yes, then I get it).
4) Is my disease burdon still high?
5) Am I making average progress with the PCR values?
6) Is PH- CML better than PH+ CML?
7) Does having PH- CML mean there is something else causing the BCR-ABL fusion protein (or is the mutation probably there, but in too small to be detected)?
8) If you are considered in a CCyR, then do you have PH- CML?