I don't get the headaches. I get tons of other side effects. But I take the Sprycel just before going to bed, around 11 pm. That was based on reading what other people had said about it here on the boards.
Sprycel does not upset my stomach or give me the headaches, but I went straight on Sprycel at diagnosis, a couple of weeks before FDA approval of Sprycel for first line defense. It seems the headaches are reserved for folks that were on Gleevec or Tasigna and switched.
Not to scare you, as I am ridiculously sensitive to drugs and have the devil of a time just using over the counter medication, I do experience tongue lesions, brain fog which as turned more into distractedness, there was a lot of bone pain (which onc said was the drugs cleaning out my bone marrow), shortness of breath (not pleural effusion, had that tested six ways to sunday), loss of apetite, insomnia, a weird burning sensation in my feet when I try to go to sleep, hair loss, amazing fatigue in the beginning, but this is getting better, I just developed a body sized rash with what I would otherwise classify as prickly heat, but it is taken to the next level and I am on Prednisone this week. The prednisone has the wonderful effect of giving me energy, but also makes me nuts.
But hey, no headaches! And my CBC numbers dropped like a stone back to normal ranges in 2 weeks!
Best of luck, and please ask me anything else you want to know about Sprycel. I have only been on it since September 30, 2010.