2 replies to this topic

[Sneezy12]

I recently developed a slightly elevated BUN-a value of 24, with upper limits of normal 23- ( I had eaten a lot of meat the preceding 2 days and resumed a mild exercise program ). Serum Creatinine was normal at 1.25. Does Gleevec cause such an elevation? Thanks, Frank

[Trey]

Yes.  Your levels are no worry.

Gleevec "was associated with focal mineralization and dilation of the renal  tubules, tubular nephrosis, and increased BUN and creatinine in animal  studies."

http://www.drugs.com...l#ixzz0p5Bf42LE  (see Renal section)

Glad to see the Serum Creatinine is back to normal.

[Sneezy12]

Thank you, Frank