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[CaroleL]

• Have not posted in a while, but.....saw onc (Dr. Talpaz) at U of M today and have some disconcerting reports.  Counts remain low - WBC - 2.5, HgB - 9.2, ANC 1.9, however, Uric Acid is now up to 8.8 and Creatinine is 1.2 (up from 1.2 a month ago).   I was given a prescription for Allupurinol and a referral for a nephrologist.  I will continue Neupogen 100mcg SQ twice weekly.  (wondering if I still have healthy stem cells that can be stimulated with the Neupogen.)   I declined Procrit for the anemia.  FISH and PCR were drawn but reports will not be available for a week or so.  Seems my counts cannot get high enough to raise the G to 400mg!!  Any advise?  currently feeling a bit overwhelmed!  Switch to Sprycel deferred since it is more immunosuppressent than Gleevec.

[Trey]

Neupogen has been shown to be the cause of high uric acid levels, and is reversible after stopping Neupogen therapy (which means that it is not necessarily a "kidney problem"):

"Spontaneously reversible elevations in uric acid‚ lactate dehydrogenase‚ and alkaline phosphatase occurred in 27% to 58%..."

http://www.drugs.com/sfx/neupogen-side-effects.html