Most common mutation
#1
Posted 08 December 2017 - 11:48 PM
Does anyone know this.
#2
Posted 11 December 2017 - 10:40 AM
I'm no expert, but when I was diagnosed, I was told I had the most common form of CML, which was the translocation of chrosomone 9 and 22, which she referred to as the Philadephia chromosome.
DX 3/30/2016 WBC 484.2 FISH 95.3
took Hydrea 3/30-4/11
taking Sprycel 100 mg since 4/5
10 day break from Sprycel for platelet count of 12 4/26-5/8
7/07/2016 1.47% (IS)
9/30/16 BMB PCR .1259 switched to new onc
12/30/16 PCR .1569
4/7/17 PCR .0904 MMR
7/14/17 PCR .0520
12/1/17 PCR .0148
#3
Posted 11 December 2017 - 07:19 PM
My guess would be P210, I believe this is what they usually test for with the pcr test.
dx cml 7/2012; 100 mg sprycel; splenectomy 9/2012; reached prcu 10/2013; dx smoldering myeloma 1/2015; 80 mg sprycel 12/2015; 50 mg sprycel 7/13/16; discontinued sprycel 11/15/16
#4
Posted 12 December 2017 - 10:02 AM
Kinase or chromosome?
#5
Posted 13 December 2017 - 03:29 PM
#6
Posted 13 December 2017 - 07:12 PM
Kinase:
https://www.ncbi.nlm...les/PMC4581365/
Chromosome:
t(9,22) -- aka Philadelphia Chromosome. There are different types, and you can read about them at Trey's CML Blog:
http://treyscml.blog...ics-on-cml.html
Likely you just need more dosage.
#7
Posted 13 December 2017 - 07:34 PM
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