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Most common mutation


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#1 jmoorhou

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Posted 08 December 2017 - 11:48 PM



Does anyone know this.
Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis

#2 beno

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Posted 11 December 2017 - 10:40 AM

I'm no expert, but when I was diagnosed, I was told I had the most common form of CML, which was the translocation of chrosomone 9 and 22, which she referred to as the Philadephia chromosome.


DX 3/30/2016 WBC 484.2 FISH 95.3

took Hydrea 3/30-4/11

taking Sprycel 100 mg since 4/5

10 day break from Sprycel for platelet count of 12 4/26-5/8

7/07/2016 1.47% (IS)

9/30/16 BMB PCR .1259 switched to new onc

12/30/16 PCR .1569

4/7/17 PCR .0904 MMR

7/14/17 PCR .0520

12/1/17 PCR .0148


#3 mdszj

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Posted 11 December 2017 - 07:19 PM

My guess would be P210, I believe this is what they usually test for with the pcr test.


dx cml 7/2012; 100 mg sprycel; splenectomy 9/2012; reached prcu 10/2013; dx smoldering myeloma 1/2015; 80 mg sprycel 12/2015; 50 mg sprycel 7/13/16; discontinued sprycel 11/15/16


#4 Trey

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Posted 12 December 2017 - 10:02 AM

Kinase or chromosome?



#5 jmoorhou

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Posted 13 December 2017 - 03:29 PM

Either...my wbc is going up....I've been on reduced dose for almost a year..will get bcrabl test soon.
Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis

#6 Trey

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Posted 13 December 2017 - 07:12 PM

Kinase:

https://www.ncbi.nlm...les/PMC4581365/

 

Chromosome:

t(9,22)  -- aka Philadelphia Chromosome.  There are different types, and you can read about them at Trey's CML Blog:

http://treyscml.blog...ics-on-cml.html

 

Likely you just need more dosage.



#7 jmoorhou

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Posted 13 December 2017 - 07:34 PM

Hope so, thanks Trey.
Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis




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