3 replies to this topic

[scuba]

How many of you have trisomy 8 present even if CML is "undetected"?

 

https://www.nature.c...pdf?origin=ppub

 

The recent paper suggests that trisomy 8 in and of itself is not associated with poor outcomes (advancing disease), but that it should disappear over time with continued TKI treatment.

 

That has not happened in my case. I still have trisomy 8 even though my CML is "undetected". It is suggested that as long as trisomy 8 is present, I will not be able to have a successful cessation attempt. 

 

Anyone else in this situation?

[Lucas]

Hey, scuba. I was in the trisomy team for a role year. it dissapear early in 2016, with my first PCRU (funny thing that when it dissapear i had 1% blasts in my marrow, what my doctor told me it was normal). Now i hovering around low detectable. Fingers crossed everything's fine now. have a check late this month. Cheers. 

[scuba]

Lucas,

Consider getting your vitamin D level checked and if below 30, take supplements (vitamin D3) to increase your level to be above 50 ng/ml (but below 100 ng/ml). Vitamin D activates differentiation of blood cells particularly blasts - even leukemic ones and activates your immune system (no flu). Once I increased my vitamin D level (I maintain around 70 ng/ml), my always present blasts decreased to zero - no detection of blasts anymore since around 2014. And I was at 6% at diagnosis.

 

Just a thought.

[Lucas]

Thanks, scuba.

 

My vitamin D is fine. I live in a sunny city and eat well. I had 1% blasts in my marrow at DX and 3% in my cbc. Good luck.