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Sprycel and bone ...

Started by scuba , Aug 22 2017 08:05 AM

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4 replies to this topic

#1 scuba

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LocationHouston, Texas

Posted 22 August 2017 - 08:05 AM

https://www.scienced...70821113559.htm

https://cosmosmagazi...-of-ageing-mice

Khosla, Kirkland and colleagues tested their hunch by treating 20-month-old mice (the equivalent of 70-year-old humans) with two senolytic compounds previously identified by Kirkland's screens: quercetin and dasatinib. Quercetin is a plant-based natural product. Dasatinib is a drug used to treat leukaemia, though the doses used here were much smaller.

Mice received their senolytic cocktail once a month for four months. Those treated showed a 50% increase in their bone volume. Scans showed that not only had their bone mass increased - a finding that could be due to increased mineralization - but the structure of their bone revealed new deposition of bone tissue, increasing its strength. This ability to stimulate new bone growth is not seen with current osteoporosis drugs, says Khosla.

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale)

March 2017 PCR: 0.01% (M.D. Anderson scale)

June 2017 PCR: "undetected"

September 2017 PCR: "undetected"

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#2 Gail's

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634 posts

Posted 22 August 2017 - 01:04 PM

May make bones better, but my question is: do I look younger since taking dasatinib and quercetin???

Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088

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#3 Trey

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LocationSan Antonio, Texas

Posted 22 August 2017 - 01:08 PM

Look at Scuba's photo and you have your answer...Just sayin'

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#4 scuba

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LocationHouston, Texas

Posted 22 August 2017 - 01:20 PM

Trey - thank you! You and my wife are in agreement.

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale)

March 2017 PCR: 0.01% (M.D. Anderson scale)

June 2017 PCR: "undetected"

September 2017 PCR: "undetected"

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#5 Kali

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112 posts

Posted 24 August 2017 - 10:47 AM

Great articles, Scuba. I am going to share them with my doctor!

Diagnosed June 2014. WBC 34.6 and Platelets 710 at diagnosis. Bone Marrow Biopsy pre-op diagnosis: Leukocytosis. Post-op diagnosis: the same, Leukocytosis. No increase in blasts <1%. Quantitative BCR/ABL testing and formal chromosome analyses confirmed CML diagnosis.<p>Supplemental Report: Abnormal BCR/ABL1 FISH result t(9;22). Molecular test for BCR/ABL1 fusion transcript by RT-PCR positive for BCR/ABL1 transcripts, b3a2 at 133.561% and b2a2 at 0.001% and ela2 at 0.001%. Followup monitoring showed negative for ela2. BCRABL1 was 148.007 at diagnosis. Started Sprycel 100 mgm and blood work was normal at 3 weeks. MMR at 3 months: 10/4/14 was 0.106. Stayed in that range with one dip to 0.04 once and back to 0.1 range. Oct. 2015, BCRABL1 was not detected, following with 0.0126, 0.0092, <0.0069, 0.0000, <0.0069, 0.0000. Now on 70 mgm of Sprycel. Continuation of PCR test results: 07/07/2017, 0.0000%, now on 50 mgm of Sprycel, PCR 9/12/17 0.0074%, PCR 11/3/17 0.0000%, PCR 1/17/2018 0.0000%