Has anyone else taking Sprycel experienced dry eyes and/or changes in vision?
Sprycel and Eyes
Started by
mdh54165
, Aug 03 2017 08:38 AM
4 replies to this topic
#2
Jan0080
-
- Members
-
- 51 posts
Advanced Member
- LocationLos Angeles
Posted 03 August 2017 - 11:13 AM
After. 3 months of Sprycel 100 mg at the end of March, I lost the ability to focus using both eyes at reading distance. I am a CPA with a busy tax practice. One of my clients asked me why I was closing one eye while preparing his taxes. My eye Dr had no idea what caused the issue but we were fairly certain it was TKI mischief. My dosage almost immediately went down to 80 mg and today I am at 20 mg. As I am typing this, both of my eyes are open and I can properly focus without seeing double. My lungs are working and I am back at the gym doing 30 minutes of cardio daily. I can't begin to thank this web site including Trey and Scuba for assisting me on this journey. Fred K aka Jan0080.
Diagnosed Dec 27, 2016 started Sprycel 100 mg Jan 7, 2017. Initial PCR 77.9 after 30 days 28.4, day 79 1.4 and day 115 0.1%. That is a 99.9% reduction! Sprycel 100 mg for 3 months, 80 mg for 1 month and now at 50 mg. Hooray for Sprycel!!! PCR June 5, 2017 0.04! Dose reduction to 40 mg 6/15/2017 due to shortness of breath. 20 mg as of June 29th. PCR .02 9/11/2017. PCR .015 IS as of 12/11/2017. Lungs substantially better. Low dose Sprycel works!
Adverse Effect - At about week 6 of Sprycel sharp muscle pain that would start at 2 AM and last for about 4 hours. This lasted about 4 weeks and went away, thank goodness.
Adverse Effect - At about week 6 of Sprycel sharp muscle pain that would start at 2 AM and last for about 4 hours. This lasted about 4 weeks and went away, thank goodness.
#3
Busa
-
- Members
-
- 29 posts
Member
Posted 03 August 2017 - 01:07 PM
I've had a "stroke" in my left eye and am now blind in it... Who knows?
#4
Gail's
-
- Members
-
- 634 posts
Advanced Member
Posted 03 August 2017 - 06:07 PM
Wow! I thought it was from switching to reading e books instead of paper books. I have the unable to focus thing but only when laying on my side while I read in bed. I do fine if I close one eye or sit up.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#5
chevyflame
-
- Members
-
- 15 posts
Member
Posted 06 August 2017 - 01:00 PM
Hi Everyone,
I experienced a serious condition with my left eye. On 11/23/15 I woke up in the middle of the night with stabbing pains in my eye and went to the ER. The doctor recommended that we see an eye specialist asap.
The next morning we saw an Ophthalmologist and a specialist in diseases of the retina and vitreous.who said there wasn't adequate blood flow to my eye. I have had some cardiac emergencies and surgeries so he checked with my vascular surgeon. Since there was no change in my vascular condition, the opthamologist did some additional research and found a link to my CML.
Diagnosis: diffuse retinal hemorrhages, iritis, and neovascularization all consistent with ocular ischemic syndrome. I feel that this is a combination of his vascular disease and CML as this entity can lead to sludging and venous stasis exacerbating the ischemic disease to the point of creating the signs and symptoms he now manifests. He has now required multiple anti vascular endothelial growth factor intraocular injections and panretinal photocoagultion sessions and will likely need more treatments in the future. ( Plain language my eye was creating new veins due to lack of blood flow which untreated would have led to losing sight in the eye.)
I have some vision loss, tunnel vision and when a bright light hits my eye I lose vision completely in this eye for a time which impedes my night driving. My condition seems to have stablized for now.
Thanks to all who share their CML stories and information. Knowledge is definitely empowering.
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users
