Hi everyone
i'm on Dasatinib since 2014 and currently i started experience colon disturbance and Diarrhea
what to do to reduce stomach disturbance and diarrhea issue??
Can anyone help please
stomach disturbance and diarrhea With dasatinib
Started by
Aymansgham
, Mar 03 2017 07:56 AM
6 replies to this topic
#2
Jan0080
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Posted 03 March 2017 - 12:03 PM
Do you take Omeprazole? I take 40 mg. Do you have a gastroenterologist? Ask him. I am an amateur. I need a Phillips milk of magnesia caplet for constipation. Good luck!
Diagnosed Dec 27, 2016 started Sprycel 100 mg Jan 7, 2017. Initial PCR 77.9 after 30 days 28.4, day 79 1.4 and day 115 0.1%. That is a 99.9% reduction! Sprycel 100 mg for 3 months, 80 mg for 1 month and now at 50 mg. Hooray for Sprycel!!! PCR June 5, 2017 0.04! Dose reduction to 40 mg 6/15/2017 due to shortness of breath. 20 mg as of June 29th. PCR .02 9/11/2017. PCR .015 IS as of 12/11/2017. Lungs substantially better. Low dose Sprycel works!
Adverse Effect - At about week 6 of Sprycel sharp muscle pain that would start at 2 AM and last for about 4 hours. This lasted about 4 weeks and went away, thank goodness.
Adverse Effect - At about week 6 of Sprycel sharp muscle pain that would start at 2 AM and last for about 4 hours. This lasted about 4 weeks and went away, thank goodness.
#3
Gail's
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Posted 03 March 2017 - 08:34 PM
Shouldn't take omeprazole with dasatinib. Imodium helps the diarrhea a lot.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#4
Trey
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Posted 03 March 2017 - 09:27 PM
Hi everyone
i'm on Dasatinib since 2014 and currently i started experience colon disturbance and Diarrhea
Dasatinib (Sprycel) is not normally a cause of bowel issues. But we are all different and it could be related in your case. But I would look into other possibilities with your doctor just to be safe.
#5
hannibellemo
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Posted 06 March 2017 - 07:12 PM
Aymansgham,
I also have cyclical stool issues with Sprycel. It's not diarrhea exactly, but I have found that adding bulk, like metamucil, does help.
Good luck!
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
#6
Mayra
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Posted 20 March 2017 - 10:32 PM
I also have cyclical diarrhea with Sprycel. I'm on 100mg and for the last month it has been terrible. Last year I had a colonoscopy and the Dr. mentioned that the reason for my issues was definitely Sprycel. Just today I started taking Kefir in hopes that it will help.
#7
jmoorhou
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Posted 21 March 2017 - 12:41 AM
I had bad nausea with Gleevec that got alot better when I took it an hour after dinner instead of with dinner. Hasn't affected MMR. Not the same problem but you might want to try it.
Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis
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