Prior lung issues and Sprycel
Posted 30 January 2017 - 01:23 PM
I've had the usual amount of coughs, colds and occasional asthma wheezing, in other words, pretty normal lungs. The body has a way of encapsulating latent TB but it can be reactivated if that system breaks down.
Has anyone experienced any prior lung issues and had an exacerbation of it once on Sprycel? Only wondering since the drug causes lung issues by itself.
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
Posted 08 February 2017 - 06:00 PM
I have a lung disease called hypersensitivity pneumonitis. It was originally caused by sleeping on a goose down pillow. The effect was to reduce the transfer of oxygen from my lungs into the bloodstream. I was in remission from that after we figured out the problem. It recurred about a year ago with no apparent cause. I have been on Sprycel for a month and my lungs are getting much better. I am apparently also allergic to CML. Thank you Sprycel !
Adverse Effect - At about week 6 of Sprycel sharp muscle pain that would start at 2 AM and last for about 4 hours. This lasted about 4 weeks and went away, thank goodness.
Posted 09 February 2017 - 08:01 AM
What an interesting topic. I'm not originally from this state but I know there was a huge outbreak of histoplasmosis in this city in the 1950's. Many people still see evidence of that whenever they have chest x-rays. I don't know if there are any latency issues with it or not.
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
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