Whether it is "something to be scared about" is not the question, since there is not enough information at this point. But it does need to be investigated. I assume there was no infection/viral illness prior to this developing. Enlarged lymph nodes can be benign (including from recent illness), show sarcoidosis (discussed below), show lymphoma, or show some form of localized cancer that has drained to that node from a tumor.
Sarcoidosis is a non-cancerous enlargement of lymph nodes due to unknown reasons, sometimes an autoimmune response or rarely a response to prescription drugs. TKI drugs, especially Sprycel may rarely cause such issues, and I have seen others mention nodules near the lungs but there was not much other information given. This article describes the issue in general terms, not specific to CML drugs:
Here is some info about enlarged lymph nodes and Gleevec:
For mediastinal lymph nodes of the chest, if it is malignant (no way to know without biopsy) the prime suspects would be lymphoma or lung cancer, although they are not the only possibilities.
Here are some questions to ask the doc:
1) Which lymph node is involved and what tissue does it drain?
2) Is the node large enough to cause concern?
3) Should a biopsy be done? What type (needle or excision)?
4) Should other areas be scanned for enlarged nodes?
5) Could this be caused by Gleevec? (Probably won't know, but bring up the issue)
6) What is the plan for discovering the underlying issue?
I would not automatically assume it is caused by TKI drugs, since that would not be the proper way to proceed in case it has some other cause which needs to be discovered. But attempts to discover the cause of lymph node enlargement can be difficult.
Edited by Trey, 25 August 2016 - 04:34 PM.