Early TKI Responses Predict CML Survival, Especially With Dasatinib
Posted 16 June 2016 - 03:56 PM
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
Posted 17 June 2016 - 09:12 AM
This is nice, but not big news, it seems to me. It still seems to me to say, if you respond early and well, you are more likely to respond early and well. Plus, I'm not real impressed by "long term" being defined as five years. Most everyone, on any TKI, will get five years. I understand completely that studies are limited by how long they have been able to be run so far. I just don't think a conclusion can be made yet that having a deeper and earlier response (which you get with the second generation drugs) wins you victory in the long haul - say, twenty or thirty years. This simply cannot prove that. I could get all cynical and say perhaps this is a drug company push to get doctors to prescribe the expensive ones first, now that generic gleevec is soon to go down in price?
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.
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