Posted 02 June 2016 - 11:53 AM
PCR is expressed as a percent (or should be). Specifically it is a ratio of bcr-abl proteins (produced by the CML cells) to the normal abl control protein. bcr-abl/abl is what is reported. The value you cite above: 120,000 makes no sense as a PCR lab test result.
FISH is a percentage of CML cells observed under the microscope. Eighty Seven percent of your cells under the microscope were CML at diagnosis. Many patients start out with 100% of their observed cells as CML - or FISH = 100%.
FISH is a true number of cells measure. PCR is a molecular measure and roughly correlates to number of cells.
During successful treatment, FISH will fall to zero (i.e. cytogenetic remission). This is a very important result to achieve. When FISH falls to zero, PCR is usually around 1%.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"