I want to compile a list of things I can take while on Sprycel.
This is my only prescription drug. A dour to the excess of drug interaction warnings on the web and on th Bristol Meyers Squibb insert....I have concerns. All the small dose convenience meds like NSAIDs are out and stomach meds like Pepto or Pepsid or Tums, but what about things for a cold or allergies or whatever.
What do people take? Right now I have bronchitis and am coughing and congested...doc ordered Codine all I want is to clear my chest...anybody have a list of stuff they have found safe?
Sprycel and regular old over the counter meds
Started by
DebDoodah22
, Apr 14 2016 06:52 PM
5 replies to this topic
#2
Trey
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Posted 14 April 2016 - 09:07 PM
Since Sprycel has the shortest half-life in the body (5 hours) of any of the TKI drugs, you could take most other drugs as long as they are taken over 5 hours after you take the Sprycel, and also several hours before. Antacids are fine as long as they are not taken within a couple hours of taking Sprycel since the issue is absorption from the alimentary canal. That absorption happens very quickly, about 90% within one hour. NSAIDs are less clear, but time separation helps limit any interaction.
#3
rcase13
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Posted 14 April 2016 - 09:25 PM
If Sprycel has the shortest half life why don't you have to take it twice a day like Tasigna.
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg
Cancer Sucks!
#4
mscl
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Posted 14 April 2016 - 09:36 PM
What about taking fish oil with Sprycel?
Dx 2/10/12.
Sprycel 100. mg.
10/2015, Pleural effusions, both sides, about a 3-4 week break in Rx, reduced to 70 mg.
PEs, weren't completely gone, started building back up, about a 6-8 week break in Rx.
01/2016, Reduced to sprycel 50 mg.
10/2016, developed severe skin rash, mainly upper arms and upper legs, smaller rashes on lower arms, lower legs, upper back/neck. Rx break of about 6 weeks.
1/25/17, reduced to Sprycel 20 mg.
7/19/17, still at 20 mg Sprycel, undetectable.
11/9/17, 20 mg Sprycel, undetectable.
Sprycel 100. mg.
10/2015, Pleural effusions, both sides, about a 3-4 week break in Rx, reduced to 70 mg.
PEs, weren't completely gone, started building back up, about a 6-8 week break in Rx.
01/2016, Reduced to sprycel 50 mg.
10/2016, developed severe skin rash, mainly upper arms and upper legs, smaller rashes on lower arms, lower legs, upper back/neck. Rx break of about 6 weeks.
1/25/17, reduced to Sprycel 20 mg.
7/19/17, still at 20 mg Sprycel, undetectable.
11/9/17, 20 mg Sprycel, undetectable.
#5
Gail's
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Posted 15 April 2016 - 01:06 PM
My patient insert with dasatinib says antacids like tums ok if 2 hours or more from dose of dasatinib. I can't take omeprazole for heartburn at all and was switched to famotodine instead. It doesn't work as well as omeprazole and has to be 12 hours or more after dasatinib. I wonder why no one has thought of an acid producing drug to create the environment needed for dasatinib then let you take something to reduce acid after dasatinib absorbed.
I've given up on trying to figure out what I can & can't take with TKI s. So I just contact my pharmacist and run it all by them. Very important resource for us because they really do know more about the meds than our oncs and have a vested interest in keeping you safe so their advice doesn't create a liability.
I've given up on trying to figure out what I can & can't take with TKI s. So I just contact my pharmacist and run it all by them. Very important resource for us because they really do know more about the meds than our oncs and have a vested interest in keeping you safe so their advice doesn't create a liability.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#6
scuba
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Posted 15 April 2016 - 03:01 PM
Since Sprycel has the shortest half-life in the body (5 hours) of any of the TKI drugs, you could take most other drugs as long as they are taken over 5 hours after you take the Sprycel, and also several hours before. Antacids are fine as long as they are not taken within a couple hours of taking Sprycel since the issue is absorption from the alimentary canal. That absorption happens very quickly, about 90% within one hour. NSAIDs are less clear, but time separation helps limit any interaction.
It's not just the half-life of Sprycel to consider, but the half-life of the other drugs. If they last longer than 20 hours or so, then the next time one takes Sprycel there could be an interaction.
Just something to consider.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
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