9 replies to this topic

[scuba]

Another "tool" to attack CML?

 

Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells

 

http://www.ncbi.nlm....pubmed/24928376

 

Disclaimer up front: Quercetin is not a cure for CML or cancer in general. It is yet another plant derived compound (skin of apples) when in sufficient concentration inhibits CML cells. I added Quercetin to my regimen a month or so ago along with Curcumin and other "roots". We'll see if it helps.

 

My goal is to stop taking Sprycel and maintain PCR < 0.01%. 

[Harper3994]

Very interesting...do you think it is important that we take circumin? Someone told me all of us taking these tki' s should take milk whistle. The oncologists Don't tell you anything

[gerry]

I'd probably avoid Milk Thistle, my pharmacist commented anything that interacts with the liver probably isn't good with a TKI. Milk Thistle is usually used as a diuretic.

[scuba]

I have never had spleen pain. In fact, when I was diagnosed with CML, my spleen was normal (size, feeling). No tenderness or anything. My WBC was not too high (17,000 at diagnosis), however, so my spleen was probably not reflecting the disease yet. 

 

I take Quercetin most days when I think about it since the beginning of this year. It's not a 'regimen' like Curcumin, vitamin D3 and vitamin C that I take (and Magnesium). I even take milk thistle from time to time. 

[gerry]

I took celery seed to help with the fluid retention and for some reason it seemed to help me with the muscle cramps. Avoided the milk thistle due to not wanting my liver to work too well and remove the Gleevec too quickly out of my system.

[Sandrea]

Hello, this is interesting topic for me, I also accept quercetin every day for more than half a year (I was diagnosed with CML in April 2015 and taking imatinib from June 2015).

Scuba, can I ask you, what dose of quercetin you take a day? I also take milk thistle each day for two months for liver support, this brand: http://ru.iherb.com/...ggie-Caps/13870.

For gerry: 

There it is written that milk thistle does not remove the Gleevec too quickly, but INCREASE the serum level of TKIs in the blood stream - http://www.nationalc...od-interactions

 

P.S.  Excuse my bad English, I used on Google Translate

[gerry]

Sorry my mistake, I remembered there was some sort of interaction between them. I gave it a miss as I didn't want to increase my side effects.

[Harper3994]

How much vitamin D3 should we be taking?

[scuba]

How much vitamin D3 should we be taking?

 

The Mayo clinic reports:

 

http://www.mayoclini...ng/hrb-20060400

 

and

 

https://ods.od.nih.g...thProfessional/

 

I don't follow these recommendations. I take 5,000/10,000 IU's of vitamin D3 (which is converted to vitamin D in the body) every other day in winter and 5,000 IU's per day in summer. I do this to maintain a blood vitamin D level above 60ng/ml and below 80ng/ml. Some articles report levels above 60 are not good, some say above 80, some say above 100. There is no consensus. But I have learned that increasing vitamin D by itself without balancing with other co-vitamins is why this may be true:

 

http://articles.merc...ns-d-and-k.aspx

 

http://articles.merc...-d-mistake.aspx

 

At CML diagnosis my vitamin D level was 17 ng/ml. I hate to think how many years I lived this way. I would get colds and flu like clockwork. Not any more. Not since 2013 have I been "sick". Normal range is considered between 30-50 ng/ml. But this is to prevent Rickets. You should have your blood tested twice a year. Each person metabolizes vitamin D a little differently. Vitamin D in the amounts I take should also be taken with vitamin K2. The two vitamins work together. And overdosing on vitamin D is very difficult when sufficient levels of K2 are available. But vitamin D is fat soluble and will build up in the body if taken to excess. Testing is very important if you are going to supplement.

 

For normal health - 1,000 to 2,000 IU's per day is considered safe. I have CML cancer, so I don't follow the "normal" recommendations.

[Harper3994]

Thanks for this info and explaining it so well. Why can't the doctors do the same. Nurse practitioner just told me my BCR-ABL is 0.295 percent...log reduction 3.045. Diagnosed July 2015. Is that good? She is not very clear when explaining...has a strong accent.