JPD - I don't know the answer to your question about CML and stress. But as for the stress of the divorce you're going through, the usual advice applies: it would be worth it to see a therapist, even for only a few sessions; take care of yourself the way you know you should: eat right, get outside, exercise in a way you like, keep to a good sleep/wake schedule; and lastly, try to change your perspective on this as a challenge and an opportunity - the goal is to come out on the other side with a better, LESS stressful life. On divorce in general - keep to the high road - can't stress that enough - because when it's all over, a good conscience is going to be your key to a good rest-of-your-life. Which you have all ahead of you!
P.S. When I start that waking up at 3 AM thing (and/or 5 AM), I know it's a sign that Something Big is on my mind. You know what yours is, so at least you don't have to puzzle it out. Try this to get back to sleep: tell yourself that you know what this is about, think a LITTLE bit about any possible grand revelation the waking up might have revealed (prob'ly nuthin' there), that the time for thinking and doing is in the daytime and that you promise yourself you will take it up tomorrow, but right now you must put the monkey mind to sleep. Then try to empty your mind by the meditation method (small "m"), because you have "freed" yourself from thinking. (You CHOOSE not to think.) This usually works for me, but it takes practice.
Dx July 2009 on routine physical. WBC 94. Started Gleevec 400 mg Sept 2009. MMR at 2yrs. Side effects (malaise, depression/anxiety, fatigue, nausea, periorbital edema) never improved. Kidney issues developed because of Gleevec. Switched to Sprycel 70 mg in Aug 2011. Above side effects disappeared or improved. Have been MR3.5 - 4.5 ever since. Two untreated pleural effusions followed by one treated by stopping Sprycel Jan 2017. After 9 weeks, PCR showed loss of MMR; re-started Sprycel at 50 mg and in 3 months was back to <0.01% IS. Pleural effusion returned within a couple of months, same as before (moderate, left side only). Stopped Sprycel 50 mg for 12 weeks; pleural effusion resolved. At about a monthoff the drug, PCR was 0.03; at 11 weeks it was 2.06 - lost CCyR? Have returned to 50 mg Sprycel for 3 weeks, intending to reduce to 20 mg going forward.