I assume you have not posted here previously about him. So welcome to our group.
First, it is certainly a very good idea to repeat the PCR test. Sometimes there are errors.
But given the complex translocation, some additional issues should be addressed. Drug response for three-way translocations is not as easy to predict as for the standard CML translocation which is t(9;22). Your husband has a t(8;9;22) translocation. It usually takes a couple years to see whether the long term response to TKI drugs will continue to be as good as the short term drug response for these complex translocations. So your husband is at the point where he will find out. So a fast initial response is not always continued for complex translocations, but only time tells the story.
Did the Onc tell him whether the diagnosis was CML or was it Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)? I ask because some of the three-way translocations where chromosome 8 is involved can be ALL leukemia, not CML. I would ask the Onc the following:
1) Is the diagnosis CML or Ph+ ALL? What is the basis for that conclusion?
2) Was a Flow Cytometry test done at diagnosis? (If a Flow Cytometry was not done, the Onc does not know the true diagnosis). Did it show involvement of significant numbers of lymphoid cells in the leukemia? If yes, can Ph+ ALL still be ruled out?
3) Should another Flow Cytometry test be done now?
It is important to distinguish between CML and Ph+ ALL. Although CML patients have a very high rate of long term drug response (although switching drugs may be required), Ph+ ALL drug response can be less predicable and sometimes short lived. Knowing this information can help your husband be better equipped to deal with this disease.