Anyone on Ponatib?
Posted 09 August 2015 - 03:02 PM
Posted 09 August 2015 - 03:44 PM
I went back to a lower dose of Sprycel, then earlier this year to Bosutinib.
Do you know why your doctor skipped Tasigna and Bosulif. Do you have the 315i mutation, which only responds to Ponatinib?
Posted 09 August 2015 - 03:58 PM
Posted 10 August 2015 - 05:10 PM
I took ponatinib after failing Tasigna and Sprycel. I started out at 15 mg then dosage was raised to 30 mg and finally to 45 mg. My PCR went down to an all time low of 2.9 but because it rose to 6 my Dr. switched me to Bosulif as of last week. From my experience the side effects to watch out for while taking ponatinib are extremely low blood counts. Ponatinib made me transfusion dependent so make sure that your Dr. monitors your blood counts regularly. Currently, my blood is tested 3x a week. Also, ponatinib was very hard on my skin. It was as if I had a chemical burn from the inside out with redness and constant peeling like I had a bad sunburn. Make sure you moisturize your skin religiously because my skin got extremely dry while taking this drug. This drug is also very constipating so stay ahead of that problem by drinking lots of water, having a good diet, and perhaps adding colace daily. Good luck to you - this is the strongest TKI out there and it has worked wonders for many people, but unfortunately not in my case.
BTW, anyone out there on Bosulif???
Posted 10 August 2015 - 10:52 PM
I have been taking Bosulif for about 5 months, although my dose was reduced from 500mg to 300mg after I had some issues in the first month. I just had my BCR-ABL test after 3 months at 300 and it is roughly MMR (my best reading ever).
I would recommend Bosulif to Melb81 and her doctor. What is your current BCR-ABL level?
Posted 11 August 2015 - 12:23 PM
There are probably about 10 folks here taking Iclusig. Several because they have the T315i mutation and it is the only drug that works against it.
Starting most of the drugs, even after taking another one previously, can be rough for a while. You should be able to work through it and see improvement in side effects.
What was the best response level you achieved on Sprycel? What was considered the drug failure point?
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