Posted 30 June 2015 - 08:51 AM
...that dasatinib inhibits proteins that promote cancer growth as expected but also suppresses proteins that protect against cancer...
That idea makes me a little nervous. Overall I have mixed emotions about dasatinib (Sprycel). I was on it for about four years, and Sprycel did an unbelievable job quickly bringing me to PCRU. I had a host of the typical side effects but I felt that all things considered the drug was keeping the cancer away so I could live with the ill effects. Additionally, I wasn't REALLY sure which effects were caused by the drug and which were a result of old age or some other variables.
However...I am currently in a TKI stop trial and have been drug free for about a month. I now know exactly which side effects were Sprycel caused and I am really shocked at the positive difference in my overall well being now that the drug has been removed from the equation.
TKI's are a blessing to be sure. But there is still much to learn about them. It's good that many scientists are "on the case"!
Posted 30 June 2015 - 04:08 PM
Each TKI has strengths and weaknesses. The article discusses inhibiting the SRC family of kinases, and the TKIs which do this are Sprycel, Iclusig, and Bosulif. Gleevec and Tasigna do not inhibit SRC kinases. Inhibiting the SRC kinases is believed to be useful in the fight against Gleevec resistant CML, and possibly helps especially with higher order leukemic stem cells which use alternate pathways beside the BCR-ABL route.
Posted 30 June 2015 - 06:06 PM
I felt the same way when I had to stop taking Gleevec for 7 weeks to allow my liver enzymes to return to normal. I thought I felt pretty good on Gleevec, but it wasn't until I stopped taking it that I realized what feeling good really was!
Interestingly, I didn't experience that same relief when I stopped taking dasatinib for my pleural effusion for almost 9 weeks. Perhaps, because I felt so crappy anyway at that tiime.
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
Posted 30 June 2015 - 06:25 PM
Diagnosed Oct 2013 Started 600mg of Tasigna on Nov 4th. Lowered dose a few months later to 300mg due to side affects stayed here declining PCR until March 2015 small jump from 0.0072 to 0.0083 scarred my doc into full dose of Tasigna again 600mg(been miserable since) but reached PCRU 06/15/2015(next test) and have been there ever since. Hoping to have another little one. I have the support of my doc to go off anytime, just scared to jump. might go two years PCRU but he said it wont make much of a difference. I just figured I could possibly go into a trial while preggers if I got the two years behind me.
Nov 8th 2017 went off Tasigna
Dec 1st PCRU off TKI
Jan 5th PCR Detected .0625
Feb 1st PCR Detected .7815
Added 8-6 grams Curcumin daily in Feb
March 3rd PCR Detected 3.2646 YIKES!
stopped trying for baby after February reading. will start new TKI march 16th 2017 (Sprycel)
FYI I'm not done trying for my last little one.
Posted 30 June 2015 - 10:12 PM
Posted 01 July 2015 - 10:53 AM
Trey vague question but does that mean gleevec and tasigna may be the better way to go?
Not better, but different. I do not believe any of the CML TKI drugs are just plain "better" or "stronger" or anything else without further clarifying what that means.
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