I've been on Gleevec for a year now, and I'm very happy with it -- good response and no side effects worth mentioning, none. Reading several threads, I find people who were forced to leave gleevec for some other tki after 3 years, 6 years, whatever.
I'd like to stay on gleevec for as long as I need tki's. Is that reasonable? Or does everyone go through this movement from one drug to another? Has anyone been on gleevec for say 20 years, and never changed?
What is the longest time on gleevec?
Started by
Dom
, Apr 10 2015 08:44 PM
5 replies to this topic
#1
Dom
-
- Members
-
- 186 posts
Advanced Member
- LocationNew Jersey
Posted 10 April 2015 - 08:44 PM
Diagnosed in February 2014. Started Imatinib 400 in April.
2014: 3.18 0.91
2015: 0.22 0.16 0.04 0.55
2016: 0.71 0.66
(Started Imatinib 600 in April 2016)
2016: 0.42 0.13 0.45
2017: 0.17 0.06 0.10 0.06 0.34
#2
Lucas
-
- Members
-
- 215 posts
Advanced Member
Posted 10 April 2015 - 09:26 PM
Impossible. Gleevec was approved in 2000-2001
#3
jmoorhou
-
- Members
-
- 314 posts
Advanced Member
- LocationOutside of San Francisco
Posted 10 April 2015 - 09:42 PM
My Onc told me she has someone who has been on for 13 years with no problems. The LLS gave a webinar and an expert said the main reason people have to switch is because they didn't take the Gleevec as directed, e.g. they didn't take it if they were taking a hike for instance...
Our resident expert CML Trey from Texas probably knows much more about CML than your Oncologist (like five times as much).
You might ask him or he might see this question and answer.
Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis
#4
Trey
-
- PS Beta Group
-
- 1,705 posts
Advanced Member
- LocationSan Antonio, Texas
Posted 10 April 2015 - 09:43 PM
A few started in 1999 during clinical trials and remain on it.
#5
Lucas
-
- Members
-
- 215 posts
Advanced Member
Posted 11 April 2015 - 05:20 AM
I have a friend who's on gleevec since 2003 and never chances. He's a childhood friend and is my neighbour. Crazy, isn't it?
#6
lanadal
-
- Members
-
- 25 posts
Member
- LocationVancouver, Washington
Posted 11 April 2015 - 04:05 PM
I've been on Gleevec since April 2003. My PCR levels went up once in the first 2 years. I took a course of Interferon (Yuck! Awful Stuff) with the Gleevec and my levels went back down. Have alternated between zero, weak positive, and sometimes a PCR @ .001 or .003 ever since.
My facts:
Diagnosed 2003 and have taken Gleevec 400 mg until recently. I am now taking 200 mg and will go have PCR testing every three months to see if all stays relatively stable. Have bounced between PCRU, PCR "weak positive", and .005 ever since. Had a brief rise in PCR in 2005 for which I added Interferon (Yuck!) for 6 months which sent me back to previous levels and left me with neuropathy.
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users
