My husbands rt-pcr results are positive for b3a2 19.942% detected and b2a2 0.754% detected (p210) and e1a2 0.001% detected(p190). What does this mean?
don't understand pcr results
Started by
tlb3868
, Feb 25 2015 07:31 PM
14 replies to this topic
#2
Trey
-
- PS Beta Group
-
- 1,705 posts
Advanced Member
- LocationSan Antonio, Texas
Posted 25 February 2015 - 10:19 PM
It means he has two types of the leukemic white blood cells. Most people have either b2a2 or b3a2. In technical terms, he has two types of Philadelphia Chromosome breakpoints. I also have the same two and have done well. Although the e1a2 has a very low number it is not really there at all, just a test report issue.
To get his PCR total you must add the b2a2 and b3a2 together. So his total PCR is 19.942 + .754 = 20.696%
How long has he been taking the CML TKI drugs?
#3
tlb3868
-
- Members
-
- 31 posts
Advanced Member
Posted 25 February 2015 - 11:20 PM
He's been on gleevec for 6 years. He's been off his meds since December though from stomach issues. Awaiting another
surgery after he gets clearance from heart and lung doctors. I'm just hoping his cml is in check. His white count is already up to 52,000. His oncologist said he wants to put him on sprycel. Just not until he has an ultrasound for his heart. Getting that done on the 6th. Thanks for the info
surgery after he gets clearance from heart and lung doctors. I'm just hoping his cml is in check. His white count is already up to 52,000. His oncologist said he wants to put him on sprycel. Just not until he has an ultrasound for his heart. Getting that done on the 6th. Thanks for the info
#4
Trey
-
- PS Beta Group
-
- 1,705 posts
Advanced Member
- LocationSan Antonio, Texas
Posted 26 February 2015 - 09:29 AM
His CML needs to be treated more aggressively. He has lost a considerable amount of response. Sprycel would be a reasonable approach.
#5
Gail's
-
- Members
-
- 634 posts
Advanced Member
Posted 26 February 2015 - 03:15 PM
When is the pcr usually done? Is a baseline done at diagnosis then follow up for response a few months later? My test results so far look like garden variety CML but wondering about more specific analysis of the cells. Which I think is what pcr is about, right?
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#6
tlb3868
-
- Members
-
- 31 posts
Advanced Member
Posted 27 February 2015 - 12:24 PM
His fish test results say
Two hundred interphase nuclei were examined and reveled a bcr\abl1 translocation in 85.5% of nuclei. That's sounds bad to me. Worried
Two hundred interphase nuclei were examined and reveled a bcr\abl1 translocation in 85.5% of nuclei. That's sounds bad to me. Worried
#7
Trey
-
- PS Beta Group
-
- 1,705 posts
Advanced Member
- LocationSan Antonio, Texas
Posted 27 February 2015 - 02:21 PM
It is not good. His CML needs to be treated aggressively. He needs to change drugs and start right away. He can probably still respond to one of the drugs, but if it were me I would forget about concerns over other health issues and treat the CML aggressively and immediately.
#8
tlb3868
-
- Members
-
- 31 posts
Advanced Member
Posted 27 February 2015 - 02:51 PM
That's what I thought too. But he has a twisted bowel and it needs to be repaired its causing obstruction. Surgeon says it needs to be addressed immediately.
#9
scuba
-
- Members
-
- 1,044 posts
Advanced Member
- LocationHouston, Texas
Posted 27 February 2015 - 03:36 PM
That's what I thought too. But he has a twisted bowel and it needs to be repaired its causing obstruction. Surgeon says it needs to be addressed immediately.
Trey is correct. He needs to switch drugs (Sprycel or other) and start right away. He has lost response and the CML is expanding. Perhaps he can start even though he will have the surgery.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#10
Gail's
-
- Members
-
- 634 posts
Advanced Member
Posted 27 February 2015 - 03:44 PM
Twisted bowel could be cause of death due to perforation of the bowel from extreme pressure when the bowel tries to pass the stool thru for elimination. The perforation can lead to massive infection. Massive infection can cause death particularly in immune compromise. My mothers' death occurred 36 hours after perforation. She had just begun treatment for a recurrence of B cell lymphoma another type of white blood cell cancer. The resulting infection was not responding to massive doses of the most powerful IV antibiotics. I would do the bowel surgery immediately. If it hasn't been already done. I agree with the opinion of both your oncologist and the surgeon. Please update us.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#11
Trey
-
- PS Beta Group
-
- 1,705 posts
Advanced Member
- LocationSan Antonio, Texas
Posted 27 February 2015 - 11:16 PM
If it were me, I would delay dealing with the twisted bowel issue. It is not worth the risk of waiting to restart the CML drugs. He has lived with a twisted bowel for a long time by now -- probably over a year. Deal with it by dietary changes (liquid diet, or whatever means necessary), but the risk of delaying TKI drug treatment for the CML on a probability basis is far more serious. Your husband cannot withstand a delay of another couple months while dealing with other health issues. This is my final statement on this issue regardless of what other advice you may receive. Take it for what it is worth.
#12
Gail's
-
- Members
-
- 634 posts
Advanced Member
Posted 28 February 2015 - 01:30 AM
Tub, please clarify your husbands illness and how long he's been experiencing this.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#13
Gail's
-
- Members
-
- 634 posts
Advanced Member
Posted 28 February 2015 - 01:30 AM
Darn autocorrect. I meant TLB not tub.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#14
tlb3868
-
- Members
-
- 31 posts
Advanced Member
Posted 01 March 2015 - 08:07 PM
He's had 4 surgeries already on his stomach. Was hospitalized in December and was diagnosed with twisted bowel. He is seeing a lung specialist on the 6th to approve him for surgery. In the mean time he has not been able to take his gleevec. His onc wants to put him on sprycel but because of severe edema won't until he gets a ultrasound for his heart first. Also scheduled for the 6th.
#15
Gail's
-
- Members
-
- 634 posts
Advanced Member
Posted 02 March 2015 - 12:55 PM
Oh good! Doesn't seem to be as worrisome as I thought. Sorry for going to worst case scenario. I still think the surgeon and oncologist are on the right track.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users
