Well here it is and I don't even know what to say. I got my results back from Stanford and it says "Negative"
I'm going to celebrate : - )
Here is the copy of the report.
Clinical Indication Quantitative transcript level determination and minimal residual
disease monitoring in CML/ALL.
Result Negative
P210 0.000
log dx avg >3 log reduction
Comment
The assay did NOT detect BCR-ABL transcripts in the submitted
specimen. The RNA isolated from the specimen was of sufficient
quality and quantity as indicated by amplification of a control gene.Method (NOTE)
BCR-ABL mRNA transcripts are detected by a one step real-time RT-PCR.
A control gene (ABL) is amplified as an internal standard. Each
sample is amplified in duplicate for both the target (BCR-ABL) and
control (ABL). Quantification is determined from known calibration
standards provided by Ipsogen. This assay has a sensitivity
equivalent to 10e-4 dilution of a known BCR-ABL positive cell line.
References:
1. Gabert J, Beillard E, van der Velden VHJ et al., Leukemia, 17:
2318-2357, 2003.
2. Beillard E, Pallisgaard N, van der Velden VHJ et. al. Leukemia,
17: 2474-2486, 2003.
3. Hughes T, Goldman JM et al., Blood, 10.1182:1-92.2006.
Primer Major breakpoint (CML) and minor breakpoint (ALL)Disclaimer (NOTE)
Molecular diagnostic test results should be interpreted in the
context of clinical and other pertinent laboratory findings.
Quantitation is usually performed only for the breakpoint (either
p210 or p190) the patient is known to carry, unless specifically
requested. False negative results may be due to sampling error,
sample handling or transcript levels below the lowest limit of
detection with reagents and techniques used.
This test was developed and its performance characteristics
determined by Stanford Clinical Laboratories. It has not been
cleared or approved by the U.S. Food and Drug Administration. The FDA
has determined that such clearance or approval is not necessary. This
test is used for clinical purposes. It should not be regarded as
investigational or for research. The laboratory is regulated under
CLIA of 1988.Interpreted by K. Wilson, MD, PhD
Performed at Stanford Clinical Laboratory, 3375 Hillview Avenue, Palo
Alto, CA 94304, Dr Dan Arber, Laboratory Director
General Information
Collected:
01/26/2015 10:58 AM
Resulted:
02/06/2015 9:36 PM
FINALLY PCRU
Started by
soundoff
, Feb 17 2015 09:29 PM
8 replies to this topic
#2
mlk210
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Posted 17 February 2015 - 09:34 PM
Woo Hoo!! Congratulations!! 
7/2014 Diagnosed,8/14 Started 100mg Sprycel, 9/14 Thyroidectomy (thyroid cancer)
8/2015 Undetectable, 12/15 Plural Effusion (3 wk drug break)
1/2016 Started 70mg Sprycel, 3/16 Plural Effusion (4 wk drug break)
3/16 .014 after a wk w/o meds
4/16 Started 400mg Gleevec
4/16 Undetectable, 7/16 Undetectable, 10/16 Undetectable, 2/17 Undetectable, 5/17 Undetectable, 8/17 Undetectable
#3
acl
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Posted 17 February 2015 - 09:37 PM
Soundoff, Congratulations, I am happy for you!
Diagnosed March 2014
Imatinib 400 mg. Summer 2014, Imatinib 300 mg.
% BCR-ABL
IS-NCN
06/01/16 0.18%
24/02/16 0.11%
23/03/16 0.13%
12/05/16 0.07%
13/07/16 0.17%
12/09/16 0.12%
21/19/16 0.15%
23/11/16 0.09%
20/12/16 0.11%
19/01/17 0.07%
21/02/17 0.07%
20/03/17 0.06%
20/04/17 0.06%
20/05/17 0.07%
20/06/17 0.06%
23/08/17 0.08%
22/12/17 0.04%
#5
Darlene_Jack
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Posted 17 February 2015 - 09:51 PM
Way to go!!!!! Congrats!!! That's good to hear
One breath at a time
Darlene jackðŸŒ...
Darlene jackðŸŒ...
#6
SUE
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Posted 17 February 2015 - 11:00 PM
Congratulations, Soundoff.
Dx April 2013, FISH 62, BMB not enough for PCR test; put on Gleevec 400;
August 2013, FISH 8.7;
Oct 2013, FISH 5.6
Stopped Gleevec Nov 2013 for 6 weeks due to terrible side effects; Jan 2014 started Sprycel 50mg;
Feb, 2014 PCR 6.8
May,2014 PCR .149
Aug, 2014 PCR .015
Nov. 2014 PCRU
March, 2016 went down to 40mg Sprycel
Oct. 2016 stopped Sprycel for a couple weeks due to concern about shortness of breath. Echo showed mild PAH.
Nov 1 2016 resumed Sprycel 20 mg daily
Dec 2016 PCRU
March 2017 PCR 0.020
May 2017 PCRU
Sept 2017 PCRU
Dec 2017 PCRU
#7
Billie Murawski
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Posted 17 February 2015 - 11:07 PM
Congratulations!!!! It's Happy Dance Time. So happy for you.
#8
hannibellemo
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Posted 18 February 2015 - 06:57 AM
Congratulations, soundoff! Wonderful news!
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
#9
soundoff
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Posted 19 February 2015 - 02:05 AM
Thanks everyone it really means a lot.
It's taken almost 6 years of Tasigna to get PCRU.
It's taken almost 6 years of Tasigna to get PCRU.
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