i've just read an article about thyroid issues with tki. they said most of people did not need treatment for that and that's transitory. there are some medications for hyperthyroidism maybe you should give a chance to them and have another test in a month, but it's up to you. you had a great result with tasigna and will do well long term. thanks for the support. hope i can maintain my thyroid and solve this issue 
"Discussion
Thyroid dysfunction is a well-known adverse effect of first-generation TKI therapy (1-3). Athyroid patients with CML (31,32) or metastatic medullary thyroid carcinoma (33)
simultaneously being treated with thyroid hormones and imatinib seem to need a significant increase of the levothyroxine replacement dose. Increased nondeiodination clearance through enzyme induction has been proposed as a potential mechanism (32). However, there was no thyroid dysfunction in patients with the thyroid in situ (34). Here, we analyzed thyroid function through serial monitoring of TFTs in patients being treated with imatinib, nilotinib, and dasatinib. To avoid the potential influence of comorbidities as well as the influence of CML cells and intensive treatment regimens on thyroid function, only patients with CML in chronic or early accelerated phase and one patient with hypereosinophilic syndrome were included in the present study Thyroid abnormalities were very common with only about a third of the population being strictly euthyroid during follow-up. Both hypothyroidism and hyperthyroidism were each found in about a quarter of patients. However, these changes were mostly subclinical and transient and, according to the American Thyroid Association guidelines (30), rarely needed any treatment. Due to the transient nature of druginduced hypo-orhyperthyroidism, aswellasthemildclinical course with lack of symptoms in all but two patients, no specific treatment was initiated. The therapeutic relevance of early diagnosis of hypothyroidism or hyperthyroidism is therefore unclear. Due to the retrospective nature of this study, more detailed analyses of mechanisms were not possible. However, 4 of 18 patients (22%) with hypothyroidism and 4 of 55 patients (7%) being treated with nilotinib had evidence for an autoimmune thyroiditis, which, however, did not lead to persistent hypothyroidism. Only one of these four patients, who did not have autoantibodies, had previously been treated with interferon arguing against cytokine-induced generation of autoantibodies as a major factor. In conclusion, we found thyroid dysfunction to be common in patients with Ph-positive CML under treatment with imatinib and the second-generation TKIs, nilotinib and dasatinib. However, these abnormalities rarely implied a change in clinical management or required treatment, and never led to discontinuation of the TKI. Due to the inherent limitations of a retrospective, uncontrolled study and the sample size of our cohort no direct comparisons between different drug therapies is possible. Nevertheless, the frequency of thyroid abnormalities and occurrence of cases with evidence for thyroiditis indicates that these patients should be monitored regularly. Despite their reported kinase specificity, TKIs share still elusive off-target effects that frequently result in abnormal TFTs, including autoimmune thyroiditis. We therefore suggest careful monitoring of TFTs in second-generation TKI-treated patients".
) it was lower than a month ago. my t4 is in the normal range now and i had some anti-bodies test and i was positive for one of them (TRAB), so it seems my body is attacking my thyroid. i did not have this result on my appointment and i'll send the result to my doctor tomorrow. I'm lucky because i don't have symptoms and i hope it gets better within some months - i'm going to my sixth month on tasigna in april). It's a bumpy road, but i think i'm doing good. we always will find something to worry and we really need to relax and focus on other things. my liver and pancreas numbers were up last time and i'll have some tests within 20 days, so i hope it's normal now. good luck!
