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MMR!!!

Started by Lucas , Feb 04 2015 04:04 PM

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18 replies to this topic

#1 Lucas

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Posted 04 February 2015 - 04:04 PM

just got my 3 month pcr from tasigna and the result was 0.043% IS!! Amazing!!! I'm over the moon!

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#2 rcase13

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LocationCharlotte, NC

Posted 04 February 2015 - 04:09 PM

Congrats! I had my 3 month PCR last month and hit 0.06. Hopefully it keeps going down!

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg

04/08/2015 0.01% Tasigna 600mg

07/01/2015 0.01% Tasigna 600mg

10/05/2015 0.02% Tasigna 600mg

01/04/2016 0.01% Tasigna 600mg

04/04/2016 PCRU Tasigna 600mg

07/18/2016 PCRU Tasigna 600mg

10/12/2016 PCRU Tasigna 600mg

01/09/2017 PCRU Tasigna 600mg

04/12/2017 PCRU Tasigna 600mg

10/16/2017 PCRU Tasigna 600mg

01/15/2018 PCRU Tasigna 600mg

Cancer Sucks!

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#3 mlk210

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Posted 04 February 2015 - 04:14 PM

Congratulations to you both!!! I was down to .5% at 3 months and take my 6 month test this Friday!

7/2014 Diagnosed,8/14 Started 100mg Sprycel, 9/14 Thyroidectomy (thyroid cancer)

8/2015 Undetectable, 12/15 Plural Effusion (3 wk drug break)

1/2016 Started 70mg Sprycel, 3/16 Plural Effusion (4 wk drug break)

3/16 .014 after a wk w/o meds

4/16 Started 400mg Gleevec

4/16 Undetectable, 7/16 Undetectable, 10/16 Undetectable, 2/17 Undetectable, 5/17 Undetectable, 8/17 Undetectable

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#4 hannibellemo

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LocationNorth Central Iowa

Posted 04 February 2015 - 04:16 PM

That is wonderful news, Lucas and rcase13 - congratulations! Have my fingers crossed for you, mlk210!

Pat

"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>

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#5 simone4

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Posted 04 February 2015 - 04:35 PM

Lucas, you really deserve this good news. It has been a rocky
road for you. Hope you stay there for a long time.

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#6 Marnie

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Posted 04 February 2015 - 06:12 PM

Congrats!

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#7 SUE

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Posted 04 February 2015 - 09:01 PM

Congratulations Lucas and rcase. Good luck, mlk. Keep us posted.

Dx April 2013, FISH 62, BMB not enough for PCR test; put on Gleevec 400;

August 2013, FISH 8.7;

Oct 2013, FISH 5.6

Stopped Gleevec Nov 2013 for 6 weeks due to terrible side effects; Jan 2014 started Sprycel 50mg;

Feb, 2014 PCR 6.8

May,2014 PCR .149

Aug, 2014 PCR .015

Nov. 2014 PCRU

March, 2016 went down to 40mg Sprycel

Oct. 2016 stopped Sprycel for a couple weeks due to concern about shortness of breath. Echo showed mild PAH.

Nov 1 2016 resumed Sprycel 20 mg daily

Dec 2016 PCRU

March 2017 PCR 0.020

May 2017 PCRU

Sept 2017 PCRU

Dec 2017 PCRU

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#8 Cathy

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LocationWilloughby oh

Posted 05 February 2015 - 09:20 AM

Congratulations to you both, all ! LOL

Cathy

DX 5-2010 Started normal hydra then Gleevec for 9 months stopped working

Tasigna after 5 pills pancreatis numbers jumped up quickly

Started Sprycel 100, 8-2010 for a 3 years went down to 50 mg numbers at one point really jumped up quickly

currently on 70 mg for last 2-3 years trying to get onc to reduce dose Numbers never stabilize never MMR till 4-2017 bearly and jump up and down in and out of MMR stayed MMR for 3 months then

After 6 years on sprycel fluid on both lungs, drained still have some fluid on lungs, and currently off drug 4 months now

numbers lower then ever go figure I've never been this low of a number

last 2 tests .0686 and .0181 !!

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#9 Lucas

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Posted 05 February 2015 - 09:43 AM

thank you all!!!

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#10 pammartin

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Posted 05 February 2015 - 02:10 PM

Excellent news! Congratulations to all of you.

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#11 August1

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Posted 05 February 2015 - 03:16 PM

Congratulations. That is great news.

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#12 Melanie

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Posted 05 February 2015 - 04:40 PM

Congratulations on such wonderful news!

Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)

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#13 acl

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Posted 05 February 2015 - 05:42 PM

Congratulations on such good news Lucas and rcase13.

Diagnosed March 2014

Imatinib 400 mg. Summer 2014, Imatinib 300 mg.

% BCR-ABL

IS-NCN

06/01/16 0.18%

24/02/16 0.11%

23/03/16 0.13%

12/05/16 0.07%

13/07/16 0.17%

12/09/16 0.12%

21/19/16 0.15%

23/11/16 0.09%

20/12/16 0.11%

19/01/17 0.07%

21/02/17 0.07%

20/03/17 0.06%

20/04/17 0.06%

20/05/17 0.07%

20/06/17 0.06%

23/08/17 0.08%

22/12/17 0.04%

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#14 Lucas

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Posted 05 February 2015 - 06:55 PM

thanks again, guys, but it seems that my sample did not get on time in the lab and the sample was degradated. now i have to retest. fingers crossed!

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#15 jlegakis

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Posted 09 February 2015 - 11:01 PM

You guys seem incredible below pcr at sub 1% ! I have been on 600mg of Gleevec for 3 mos. as the 400 mg. only took my pcr down to 79% after 9 mos.I got my latest result 2 days ago and now I am at 6%- a huge drop! Is it possible in the next 3 mos. I could be where you folks are at .50% or even lower? Best Jim L