Posted 04 December 2014 - 04:18 PM
Some months back I was taking a lot of Advil (daily). My numbers were going up so I stopped taking so much. My numbers dropped but I also increased my sprycel so easy to point to sprycel for the drop. When I got pneumonia in Sep I was on a lot of Advil for fever and then I was also back to taking it daily for my pelvic pain. My numbers have jumped up a bit so I was wondering if this could be related. I stopped the Advil again. My doctor prescribed diclofenac for me for pain which I have also been trying to avoid. I had read one article that claimed ibuprofen could interfere with gleevec and the same article actually said diclofenac could help gleevec but I wasn't sure how that would translate to sprycel.
Would definitely be reassuring to see some literature on ibuprofen and TKI but I am having trouble finding stuff
Posted 04 December 2014 - 07:42 PM
The LLS search engine was broken by the website update, so I can't find it. But Sneezy posted an article link about it maybe a couple years ago, and it seemed to be well supported as I recall.
Posted 05 December 2014 - 12:43 AM
I remember reading that article at some point, but I have been directed to take ibuprofen several times over the past three years. Once when I was dealing with the initial Sprycel headaches the oncologist said to take ibuprofen instead of Tylenol because it was often easier on the stomach.
Are these new studies or have they been out for a while. With my random migraines I take OTC meds frequently, I dislike taking the prescrip meds that just knock me out for several hours.
I am interested in this topic, I hadn't heard much about what not to take except grapefruit and anti acids.
Posted 05 December 2014 - 07:27 PM
The articles supplied by Teddy say "ibuprofen should be avoided in combination with imatinib [Gleevec]." This is because the studies show that ibuprofen (Motrin) inhibits Gleevec uptake into leukemic cells, which is where Gleevec does its work. But the mechanism for Gleevec cellular uptake is hOct1, which is different than the cellular uptake mechanism for Sprycel and Tasigna. Teddy's info is certainly useful, just not the answer regarding Sprycel and ibuprofen.
Edited by Trey, 05 December 2014 - 07:28 PM.
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