Posted 17 November 2014 - 11:49 AM
Posted 17 November 2014 - 07:03 PM
If you are PCR undetectable (PCRU) then you should ask your Onc about reducing the dosage. My Gleevec cramps improved when I dropped from 400mg to 200mg daily. The other alternative is to split the dosage 200mg morning and evening, which might help a bit.
Posted 17 November 2014 - 08:19 PM
Try tonic water. It helps a bit.
Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.
Rx: 03/2012-Gleevec400. Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).
Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.
Posted 17 November 2014 - 08:23 PM
I found it worse when I took a fluid tablet and became a bit dehydrated.
Posted 17 November 2014 - 08:56 PM
I'm so grateful to be able to talk to all of you that understand what I'm feeling. Blessings to you all!!
Posted 18 November 2014 - 03:46 AM
Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).
Commenced monthly testing when MR4.0 lost during 2012.
2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)
2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)
2015: <0.01, <0.01, <0.01, 0.013
2014: PCRU, <0.01, <0.01, <0.01, <0.01
2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01
2012: <0.01, <0.01, 0.013, 0.032, 0.021
2011: 38.00, 12.00, 0.14
Posted 18 November 2014 - 10:24 AM
Taking potassium and magnesium supplements have helped reduce my cramping, which are worse when I sweat a lot during the summer heat. The TKI drugs reduce electrolytes so supplements are a good idea.
Posted 20 November 2014 - 08:24 PM
Magnesium oxide (400 mg) and calcium supplements work well for me. Staying hydrated helps, too. Mine comes and goes, so I go through a spate (like the last few weeks) where I get spasms and bad cramps.
Have you figured out what triggers them? I know anytime I squat down to look in the lower kitchen cupboards or the fridge, I'm asking for foot cramps. So now I just make my kids do stuff for me that would otherwise trigger the cramps. When they grow up and leave, I'll have to renovate my kitchen so I have those glide-out shelves.
Posted 20 November 2014 - 09:25 PM
Will splitting the dose cause any problems ? I'm getting the full dose over 24 hours so I don't believe it'll be a problem. I'm scheduled for labs in early January then onc following,I'll discuss it with him then.
Posted 21 November 2014 - 11:16 AM
Splitting dosage does not decrease effectiveness of Gleevec since it has a long half-life in the body (about 18 - 20 hours). So you are always at a reasonable plasma concentration level either way. I have split the Gleevec dosage since almost the start and did very well. Sprycel has a short half-life (about 3 - 5 hours) so splitting dosage might not work as well, but there is no data either way on that. Tasigna is normally split dosage and has a long half-life as well (15 - 17 hours).
Edited by Trey, 21 November 2014 - 11:18 AM.
Posted 21 November 2014 - 08:54 PM
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